Loading...
Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study
Dinas, Petros C Nintou, Eleni Psychou, Dimitra Granzotto, Marnie Rossato, Marco Vettor, Roberto Jamurtas, Athanasios Z Koutedakis, Yiannis Metsios, George S Flouris, Andreas D
Dinas, Petros C
Nintou, Eleni
Psychou, Dimitra
Granzotto, Marnie
Rossato, Marco
Vettor, Roberto
Jamurtas, Athanasios Z
Koutedakis, Yiannis
Metsios, George S
Flouris, Andreas D
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2018-07-18
Submitted date
Subjects
Alternative
Abstract
Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m2)] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R2=0.16, p=0.03) and BMI (r=-0.45, R2=0.20, p=0.01). Cohen’s f2 effect size analyses showed a small effect size between NPRA mRNA and BMI (f2=0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m2) and either normal weight (BMI=19-25 kg/m2; d=0.94) or overweight (BMI=25-30 kg/m2; d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation
Citation
Dinas PC, Nintou E, Psychou D et al. Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study [version 2; peer review: 2 approved]. F1000Research 2018, 7:327 (https://doi.org/10.12688/f1000research.14198.2)
Publisher
Journal
Research Unit
PubMed ID
30079239
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
Series/Report no.
ISSN
2046-1402