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Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges
Kaialy, Waseem Al Shafiee, Maen
Kaialy, Waseem
Al Shafiee, Maen
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2015-12-08
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Abstract
The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current ‘bottom-up’ and ‘top-down’ technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.
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Kaialy, W. & Al Shafiee, M. (2016) Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges, Advances in Colloid and Interface Science, 228, pp.71-79
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en
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This is an accepted manuscript of an article published by Elsevier in Advances in Colloid and Interface Science on 15/01/2016, available online: https://doi.org/10.1016/j.cis.2015.11.010
The accepted version of the publication may differ from the final published version.
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00018686