Down-regulation of nitric oxide production by droloxifene and toremifene in human breast cancer cells.
Martin, Jan H. Symonds, A. Chohan, S.
Martin, Jan H.
Symonds, A.
Chohan, S.
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2003
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Abstract
We investigated the effect of tamoxifen, 4-OH tamoxifen, toremifene droloxifene, interferon-alpha2a, interferon-alpha2b and interferon-alpha2c, singly and in combination, for their effect on nitric oxide production by MCF-7 and ZR-75-1 human breast cancer cells. Tamoxifen and 4-OH tamoxifen singly had no effect on nitric oxide production by either cell line. However, treatment with droloxifene or toremifene significantly reduced nitric oxide production by both MCF-7 and ZR-75-1 human breast cancer cell lines. Combination treatment with anti-estrogens and interferon-alpha2a interferon-alpha2b or interferon-alpha2c had no synergistic or additive effect compared to each drug singly.
Citation
Oncology Reports, 10 (4): 979-984
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PubMed ID
12792756
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Journal article
Language
en
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1021-335X