Loading...
The effect of dietary carbohydrate and fat manipulation on the metabolome and markers of glucose and insulin metabolism: A randomised parallel trial
McCullough, Deaglan Harrison, Tanja Boddy, Lynne M. Enright, Kevin J. Schmidt, Michael A. Doenges, Katrina Quinn, Kevin Reisdorph, Nichole Mazidi, Mohsen
McCullough, Deaglan
Harrison, Tanja
Boddy, Lynne M.
Enright, Kevin J.
Schmidt, Michael A.
Doenges, Katrina
Quinn, Kevin
Reisdorph, Nichole
Mazidi, Mohsen
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2022-09-07
Submitted date
Alternative
Abstract
High carbohydrate, lower fat (HCLF) diets are recommended to reduce cardiometabolic disease (CMD) but low carbohydrate high fat (LCHF) diets can be just as effective. The effect of LCHF on novel insulin resistance biomarkers and the metabolome has not been fully explored. The aim of this study was to investigate the impact of an ad libitum 8-week LCHF diet compared with a HCLF diet on CMD markers, the metabolome, and insulin resistance markers. n = 16 adults were randomly assigned to either LCHF (n = 8, <50 g CHO p/day) or HCLF diet (n = 8) for 8 weeks. At weeks 0, 4 and 8, participants provided fasted blood samples, measures of body composition, blood pressure and dietary intake. Samples were analysed for markers of cardiometabolic disease and underwent non-targeted metabolomic profiling. Both a LCHF and HCLF diet significantly (p < 0.01) improved fasting insulin, HOMA IR, rQUICKI and leptin/adiponectin ratio (p < 0.05) levels. Metabolomic profiling detected 3489 metabolites with 78 metabolites being differentially regulated, for example, an upregulation in lipid metabolites following the LCHF diet may indicate an increase in lipid transport and oxidation, improving insulin sensitivity. In conclusion, both diets may reduce type 2 diabetes risk albeit, a LCHF diet may enhance insulin sensitivity by increasing lipid oxidation.
Citation
McCullough D, Harrison T, Boddy LM, Enright KJ, Amirabdollahian F, Schmidt MA, Doenges K, Quinn K, Reisdorph N, Mazidi M, Lane KE, Stewart CE, Davies IG. (2022) The Effect of Dietary Carbohydrate and Fat Manipulation on the Metabolome and Markers of Glucose and Insulin Metabolism: A Randomised Parallel Trial. Nutrients, 14(18):3691. https://doi.org/10.3390/nu14183691
Publisher
Journal
Research Unit
PubMed ID
36145067 (pubmed)
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
© 2022 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/nu14183691
Series/Report no.
ISSN
2072-6643
EISSN
2072-6643
ISBN
ISMN
Gov't Doc #
Sponsors
Deaglan McCullough and Tanja Harrison received funding for a PhD studentship by Liverpool John Moores University.
Rights
Licence for published version: Creative Commons Attribution 4.0 International