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Anticardiolipin antibodies in patients with cancer: A case–control study
Nipu, Md Ashraful Islam Kundu, Shoumik Alam, Sayeda Sadia Dina, Ashrafun Naher Hasan, MD Ashraful Khan, Mohammad Khalil, Md Ibrahim Hossan, Tareq
Nipu, Md Ashraful Islam
Kundu, Shoumik
Alam, Sayeda Sadia
Dina, Ashrafun Naher
Hasan, MD Ashraful
Khan, Mohammad
Khalil, Md Ibrahim
Hossan, Tareq
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Other contributors
Epub Date
Issue Date
2023-03-31
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Abstract
Antiphospholipid antibodies are highly prevalent in autoimmune diseases and mainly associated with thromboembolic events, which is one of the major reasons for cancer-related mortality. Confirmed adult cancer patients were included (n = 40) with an equal number of age- and sex-matched healthy controls. The presence and concentration of anticardiolipin antibodies were investigated by the enzyme-linked immunosorbent assay using the venous blood samples. aCL antibodies were detected in 60.0% (n = 24) of the cancer patients compared to none in the healthy controls (p < 0.001). The serum concentration of aCL antibodies was significantly higher in cancer patients than controls (p < 0.001) and ranged from 89.0 U/mL to 133.0 U/mL among the aCL-positive patients. All the lung cancer patients (n = 6) were diagnosed with positive aCL, and a borderline significant association of aCL antibody positivity was observed in colon cancer patients (p = 0.051). About 72.7% of the advanced-stage cancer individuals and 81.8% of the cancer patients who underwent surgery were diagnosed with positive aCL antibodies. A significant association of aCL antibody positivity was observed with cancer patients comorbid with heart diseases (p = 0.005). The prevalence and serum levels of aCL antibodies were significantly higher in cancer patients compared to healthy controls. Cancer patients (i.e., lung, liver, and colon), at advanced-stage, comorbid with heart diseases, who underwent surgery, were more likely to be diagnosed with aCL antibodies.
Citation
Nipu, M.A.I.; Kundu, S.; Alam, S.S.; Dina, A.N.; Hasan, M.A.; Khan, M.; Khalil, M.I.; Hossan, T.; Islam, M.A. Anticardiolipin Antibodies in Patients with Cancer: A Case–Control Study. Cancers 2023, 15, 2087. https://doi.org/10.3390/cancers15072087
Publisher
Journal
Research Unit
PubMed ID
37046748 (pubmed)
PubMed Central ID
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Type
Journal article
Language
en
Description
© 2023 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/cancers15072087
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ISSN
EISSN
2072-6694
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Sponsors
This research was funded by National Science and Technology Fellowship 2019–2020, Bangladesh. The open-access publication was supported by the University of Birmingham, Birmingham B15 2TT, UK.
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Licence for published version: Creative Commons Attribution 4.0 International