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Reliability of optical coherence tomography angiography retinal blood flow analyses
Courtie, Ella F Gilani, Ahmed Capewell, Nicholas Kale, Aditya U Hui, Benjamin T K Liu, Xiaoxuan Montesano, Giovanni Teussink, Michel Denniston, Alastair K Veenith, Tonny
Courtie, Ella F
Gilani, Ahmed
Capewell, Nicholas
Kale, Aditya U
Hui, Benjamin T K
Liu, Xiaoxuan
Montesano, Giovanni
Teussink, Michel
Denniston, Alastair K
Veenith, Tonny
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2023-07-03
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Abstract
Purpose: Investigate the association between the optical coherence tomography angiography(OCTA)metricsderivedfromdifferentanalysisprogramstounderstandthe comparability of studies using these different approaches. Methods: Secondary analysis of a prospective observational study (March 2018– September 2021). Forty-four right eyes and 42 left eyes from 44 patients were included. Patients were either undergoing upper gastrointestinal surgery with a critical care stay planned or were already in the critical care unit with sepsis. OCTA scans were obtained in an ophthalmology department or critical care setting. Fourteen OCTA metrics were compared within and between the programs, and agreement was measured by Pearson’s R coefficient and intraclass correlation coefficient. Results: Correlation was highest between all Heidelberg metrics and Fractalyse (all >0.84), and lowest between Matlab skeletonized or foveal avascular zone metrics and all other measures (e.g., skeletal fractal dimension and vessel density at −0.02). Agreement between eyes was moderate to excellent in all metrics (0.60–0.90). Conclusions: The significant variability between metrics and programs used for OCTA analysis demonstrates that they are not interchangeable and supports a recommendation for perfusion density metrics to be reported as standard. Translational Relevance: Agreement between different OCTA analyses is variable and not interchangeable. The high agreement between non-skeletonized vessel density metrics suggests that these should be routinely reported.
Citation
Ella F. Courtie, Ahmed Gilani, Nicholas Capewell, Aditya U. Kale, Benjamin T. K. Hui, Xiaoxuan Liu, Giovanni Montesano, Michel Teussink, Alastair K. Denniston, Tonny Veenith, Richard J. Blanch; Reliability of Optical Coherence Tomography Angiography Retinal Blood Flow Analyses. Trans. Vis. Sci. Tech. 2023;12(7):3. https://doi.org/10.1167/tvst.12.7.3.
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37395705 (pubmed)
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© 2023 The Authors. Published by Association for Research in Vision and Ophthalmology. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1167/tvst.12.7.3
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2164-2591
EISSN
2164-2591
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Supported by the National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre (SRMRC). TV's research programme was supported by Medical Research Council. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
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Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International