Loading...
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Paskeh, Mahshid Deldar Abad Entezari, Maliheh Mirzaei, Sepideh Zabolian, Amirhossein Saleki, Hossein Naghdi, Mohamad Javad Sabet, Sina Khoshbakht, Mohammad Amin Hashemi, Mehrdad Hushmandi, Kiavash
Paskeh, Mahshid Deldar Abad
Entezari, Maliheh
Mirzaei, Sepideh
Zabolian, Amirhossein
Saleki, Hossein
Naghdi, Mohamad Javad
Sabet, Sina
Khoshbakht, Mohammad Amin
Hashemi, Mehrdad
Hushmandi, Kiavash
Authors
Paskeh, Mahshid Deldar Abad
Entezari, Maliheh
Mirzaei, Sepideh
Zabolian, Amirhossein
Saleki, Hossein
Naghdi, Mohamad Javad
Sabet, Sina
Khoshbakht, Mohammad Amin
Hashemi, Mehrdad
Hushmandi, Kiavash
Sethi, Gautam
Zarrabi, Ali
Kumar, Alan Prem
Tan, Shing Cheng
Papadakis, Marios
Alexiou, Athanasios
Islam, Md Asiful
Mostafavi, Ebrahim
Ashrafizadeh, Milad
Entezari, Maliheh
Mirzaei, Sepideh
Zabolian, Amirhossein
Saleki, Hossein
Naghdi, Mohamad Javad
Sabet, Sina
Khoshbakht, Mohammad Amin
Hashemi, Mehrdad
Hushmandi, Kiavash
Sethi, Gautam
Zarrabi, Ali
Kumar, Alan Prem
Tan, Shing Cheng
Papadakis, Marios
Alexiou, Athanasios
Islam, Md Asiful
Mostafavi, Ebrahim
Ashrafizadeh, Milad
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2022-06-28
Submitted date
Alternative
Abstract
Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids. This review focuses on the role of exosomes in cancer progression and therapy. We discuss how exosomes are able to modulate components of the tumor microenvironment and influence proliferation and migration rates of cancer cells. We also highlight that, depending on their cargo, exosomes can suppress or promote tumor cell progression and can enhance or reduce cancer cell response to radio- and chemo-therapies. In addition, we describe how exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by focusing on their ability to transfer non-coding RNAs between cells and modulate other molecular signaling pathways such as PTEN and PI3K/Akt in cancer. Subsequently, we discuss the use of exosomes as carriers of anti-tumor agents and genetic tools to control cancer progression. We then discuss the role of tumor-derived exosomes in carcinogenesis. Finally, we devote a section to the study of exosomes as diagnostic and prognostic tools in clinical courses that is important for the treatment of cancer patients. This review provides a comprehensive understanding of the role of exosomes in cancer therapy, focusing on their therapeutic value in cancer progression and remodeling of the tumor microenvironment. Graphical Abstract: [Figure not available: see fulltext.].
Citation
Paskeh, M.D.A., Entezari, M., Mirzaei, S. et al. (2022) Emerging role of exosomes in cancer progression and tumor microenvironment remodeling. Journal of Hematology & Oncology 15, 83. https://doi.org/10.1186/s13045-022-01305-4
Publisher
Research Unit
PubMed ID
35765040 (pubmed)
PubMed Central ID
Embedded videos
Additional Links
Type
Journal article
Language
en
Description
© 2022 The Authors. Published by BMC (Springer Nature). This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1186/s13045-022-01305-4
Series/Report no.
ISSN
1756-8722
EISSN
1756-8722
ISBN
ISMN
Gov't Doc #
Sponsors
Open Access funding enabled and organized by Projekt DEAL. The work was supported by a grant from the Singapore Ministry of Education Tier 2 (MOE-T2EP30120-0016) to A.P.K. A.P.K. is also supported by the National Medical Research Council of Singapore and the Singapore Ministry of Education under its Research Centers of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore. S.C.T. is supported by the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076) and the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9).
Rights
Licence for published version: Creative Commons Attribution 4.0 International