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Iron deficiency, immunology and colorectal cancer
Omar, Hafid Phipps, Oliver Brookes, Matthew
Omar, Hafid
Phipps, Oliver
Brookes, Matthew
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2020-07-17
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Abstract
Excessive gut luminal iron contributes to the initiation and progression of colorectal cancer. However, emerging evidence suggests that reduced iron intake and low systemic iron levels are also associated with the pathogenesis of colorectal cancer. This is important because patients with colorectal cancer often present with iron deficiency. Iron is necessary for appropriate immunological functions; hence, iron deficiency may hinder cancer immunosurveillance and potentially modify the tumor immune microenvironment, both of which may assist cancer development. This is supported by studies showing that patients with colorectal cancer with iron deficiency have inferior outcomes and reduced response to therapy. Here, we provide an overview of the immunological consequences of iron deficiency and suggest ensuring adequate iron therapy to limit these outcomes.
Citation
Phipps, O., Brookes, M.J. and Al-Hassi, H.O. (2021) Iron deficiency, immunology and colorectal cancer, Nutrition Reviews, 79(1), pp. 88–97.
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Journal article
Language
en
Description
This is an accepted manuscript of an article published by OUP in Nutrition Reviews on 17/7/2020, available online at: https://doi.org/10.1093/nutrit/nuaa040
The accepted version of the publication may differ from the final published version.
Series/Report no.
ISSN
0029-6643
EISSN
1753-4887