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Bioresorbable electrospun mats of poly(D, L)-lactide / poly[(R, S)-3-hydroxybutyrate] blends for potential use in the treatment of difficult-to-heal skin wounds
Zięba, Magdalena Włodarczyk, Jakub Gupta, Abhishek Pastusiak, Małgorzata Chaber, Paweł Janeczek, Henryk Musioł, Marta Sikorska, Wanda Kaczmarczyk, Bożena Radecka, Izabela
Zięba, Magdalena
Włodarczyk, Jakub
Gupta, Abhishek
Pastusiak, Małgorzata
Chaber, Paweł
Janeczek, Henryk
Musioł, Marta
Sikorska, Wanda
Kaczmarczyk, Bożena
Radecka, Izabela
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2021-02-10
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Abstract
This study describes the preparation, physicochemical characterization and the biological studies of the polymeric delivery systems of proanthocyanidins (PCAN) extracted from Pelargonium sidoides for the potential use as wound dressings. In this study 20 wt% PCAN demonstrated good antimicrobial activity against Staphylococcus aures, a gram-positive wound pathogen. Poly(D,L-lactide) and atactic poly[(R,S)-3-hydroxybutyrate] biopolymers were used to construct biodegradable dressings. A series of polylactide/poly[(R,S)-3-hydroxybutyrate] (P(D,L)LA/a-PHB) blends, containing 10, 20, and 30 wt% of a-PHB were prepared and characterized by means of NMR, GPC, FT-IR, and DSC. Based on the findings, the P(D,L)LA/a-PHB [70/30 wt%] blend with the best thermomechanical properties (Tg value equal 37 °C) was chosen for the preparation of two kinds of electrospun mats, both with and without PCAN. About 50 % of PCAN was released from the tested mats during the first 10-12 days of incubation. The electrospun mats with elastic properties, ensuring compatibility with the wound topology, were obtained. The studies of hydrolytic degradation of the constructed mats allowed us to gain complete knowledge of their hydrolysis process, and examine the PCAN release profile as well as identify and characterize the molecular structure of the degradation products of the developed delivery system. Furthermore, preliminary cytotoxicity MTT tests (in vitro) results support the potential application of PCAN-loaded (P(D,L)LA/a-PHB) electrospun mats in wound dressings.
Citation
Zięba, M., Włodarczyk, J., Gupta, A. et al. (2021) Bioresorbable electrospun mats of poly(D, L)-lactide / poly[(R, S)-3-hydroxybutyrate] blends for potential use in the treatment of difficult-to-heal skin wounds. European Polymer Journal, 147, 15 March 2021, 110334.
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Journal article
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en
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This is an accepted manuscript of an article published by Elsevier in European Polymer Journal, available online: https://doi.org/10.1016/j.eurpolymj.2021.110334
The accepted version of the publication may differ from the final published version.
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0014-3057