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Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis
Tan, Shing Cheng Low, Teck Yew Hussain, Hafiz Muhammad Jafar Sharzehan, Mohamad Ayub Khan Sito, Hilary Kord-Varkaneh, Hamed
Tan, Shing Cheng
Low, Teck Yew
Hussain, Hafiz Muhammad Jafar
Sharzehan, Mohamad Ayub Khan
Sito, Hilary
Kord-Varkaneh, Hamed
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Epub Date
Issue Date
2022-10-20
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Abstract
Background The XRCC3 p.Thr241Met (rs861539) polymorphism has been extensively studied for its association with glioma risk, but results remain conflicting. Therefore, we performed a systematic review and meta-analysis to resolve this inconsistency. Methods Studies published up to June 10, 2022, were searched in PubMed, Web of Science, Scopus, VIP, Wanfang, and China National Knowledge Infrastructure databases and screened for eligibility. Then, the combined odds ratio (OR) of the included studies was estimated based on five genetic models, i.e., homozygous (Met/Met vs. Thr/Thr), heterozygous (Thr/Met vs. Thr/Thr), dominant (Thr/Met + Met/Met vs. Thr/Thr), recessive (Met/Met vs. Thr/Thr + Thr/ Met) and allele (Met vs. Thr). The study protocol was preregistered at PROSPERO (registration number: CRD42021235704). Results Overall, our meta-analysis of 14 eligible studies involving 12,905 subjects showed that the p.Thr241Met polymorphism was significantly associated with increased glioma risk in both homozygous and recessive models (homozygous, OR = 1.381, 95% CI = 1.081–1.764, P = 0.010; recessive, OR = 1.305, 95% CI = 1.140–1.493, P<0.001). Subgroup analyses by ethnicity also revealed a statistically significant association under the two aforementioned genetic models, but only in the Asian population and not in Caucasians (P>0.05). Conclusion We demonstrated that the XRCC3 p.Thr241Met polymorphism is associated with an increased risk of glioma only in the homozygous and recessive models.
Citation
Tan SC, Low TY, Hussain HMJ, Sharzehan MAK, Sito H, Kord-Varkaneh H, et al. (2022) Association between XRCC3 p.Thr241Met polymorphism and risk of glioma: A systematic review and meta-analysis. PLoS ONE 17(10): e0276313. https://doi.org/10.1371/journal.pone.0276313
Publisher
Journal
Research Unit
PubMed ID
36264998 (pubmed)
PubMed Central ID
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Type
Journal article
Language
en
Description
© 2022 The Authors. Published by Public Library of Science. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1371/journal.pone.0276313
Series/Report no.
ISSN
1932-6203
EISSN
1932-6203
ISBN
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Sponsors
Research in SCT’s laboratory is supported by the Research University Grant of Universiti Kebangsaan Malaysia (No. GUP-2020-076), the Fundamental Research Grant Scheme of the Ministry of Higher Education, Malaysia (No. FRGS/1/2019/SKK08/UKM/02/9), and the Higher Institution Center of Excellence (HICoE) grant of the Ministry of Higher Education, Malaysia (No. AKU49). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of this manuscript.
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Licence for published version: Creative Commons Attribution 4.0 International