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Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions
Henderson, Scott H. West, Ryan A. Ward, Simon E. Honey, Mark A.
Henderson, Scott H.
West, Ryan A.
Ward, Simon E.
Honey, Mark A.
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2018-06-20
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Abstract
The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.
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Henderson, SH., West, RA., Ward, RA., and Honey, MA. 'Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions', Royal Society Open Science, 5 (6)
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Journal article
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en
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2054-5703