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Oculomic stratification of COVID-19 patients’ intensive therapy unit admission status and mortality by retinal morphological findings
Courtie, Ella Taylor, Matthew Danks, Dominic Acharjee, Animesh Jackson, Thomas Logan, Ann Blanch, Richard J.
Courtie, Ella
Taylor, Matthew
Danks, Dominic
Acharjee, Animesh
Jackson, Thomas
Logan, Ann
Blanch, Richard J.
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Epub Date
Issue Date
2024-09-12
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Abstract
To investigate if retinal thickness has predictive utility in COVID-19 outcomes by evaluating the statistical association between retinal thickness using OCT and of COVID-19-related mortality. Secondary outcomes included associations between retinal thickness and length of stay (LoS) in hospital. In this retrospective cohort study, OCT scans from 230 COVID-19 patients admitted to the Intensive Care Unit (ITU) were compared with age and gender-matched patients with pneumonia from before March 2020. Total retinal, GCL + IPL, and RNFL thicknesses were recorded, and analysed with systemic measures collected at the time of admission and mortality outcomes, using linear regression models, Pearson’s R correlation, and Principal Component Analysis. Retinal thickness was significantly associated with all-time mortality on follow up in the COVID-19 group (p = 0.015), but not 28-day mortality (p = 0.151). Retinal and GCL + IPL layer thicknesses were both significantly associated with LoS in hospital for COVID-19 patients (p = 0.006 for both), but not for patients with pneumonia (p = 0.706 and 0.989 respectively). RNFL thickness was not associated with LoS in either group (COVID-19 p = 0.097, pneumonia p = 0.692). Retinal thickness associated with LoS in hospital and long-term mortality in COVID-19 patients, suggesting that retinal structure could be a surrogate marker for frailty and predictor of disease severity in this group of patients, but not in patients with pneumonia from other causes.
Citation
Courtie, E., Taylor, M., Danks, D. et al. (2024) Oculomic stratification of COVID-19 patients’ intensive therapy unit admission status and mortality by retinal morphological findings. Scientific Reports 14, 21312. https://doi.org/10.1038/s41598-024-68543-z
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Journal
Research Unit
PubMed ID
39266635 (pubmed)
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Type
Journal article
Language
en
Description
© 2024 The authors. Published by Nature Research. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/s41598-024-68543-z
Series/Report no.
ISSN
2045-2322
EISSN
2045-2322
ISBN
ISMN
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Sponsors
This study was funded by the National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre (SRMRC).