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Vitamin D has an aetiological role in dementias; myth or fact ?
Antoun Reyad, Ayman Girgis, Eriny Mishriky, Raafat
Antoun Reyad, Ayman
Girgis, Eriny
Mishriky, Raafat
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2020-05-30
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Abstract
Vitamin D is produced through the cutaneous transformation of 7-dehydrocholesterol by UVB-irradiation with multiple neurotrophic and neuroprotective functions, while regulating calcium-mediated neuronal excitotoxicity. Vitamin D acts mainly through binding to intracellular Vitamin D receptor (VDR) with a possible involvement of vitamin D receptor (VDR) and vitamin D-binding protein (VDBP). This is a review of evidence for the aetiological role of vitamin D in dementias and other neurological disorders. There is contradictory evidence regarding vitamin D supplementation in the prevention of dementia progression. Adding vitamin D to the standard medications used in dementia may have a future role in dementia management. Key words: Vitamin D; Dementia; Aetiology; Memantine; Dementia Medications; Neurodegenerative Disorders; Vitamin D Receptor; Neurological Disorders
Citation
Reyad, A. A., Girgis, E. and Mishriky, R. (2020) Vitamin d has an aetiological role in dementias; myth or fact, International Journal of Development Research, 10 (05), pp. 35896-35902.
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Journal article
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en
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This is an accepted manuscript of an article published in the International Journal of Development Research on 30/05/2020.
The accepted version of the publication may differ from the final published version, accessible at https://www.journalijdr.com/vitamin-d-has-aetiological-role-dementias-myth-or-fact
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2230-9926