Demystified. Human endogenous retroviruses.
Nelson, Paul N. Carnegie, P.R. Martin, Jan H. Ejtehadi, H. Davari Hooley, Paul Roden, Denise A. Rowland-Jones, S. Warren, Phil Astley, S.J. Murray, Paul G.
Nelson, Paul N.
Carnegie, P.R.
Martin, Jan H.
Ejtehadi, H. Davari
Hooley, Paul
Roden, Denise A.
Rowland-Jones, S.
Warren, Phil
Astley, S.J.
Murray, Paul G.
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Epub Date
Issue Date
2003
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Abstract
Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.
Citation
Journal of Clinical Pathology: Molecular Pathology, 56 (1): 11-18
Publisher
Research Unit
DOI
PubMed ID
12560456
PubMed Central ID
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Type
Journal article
Language
en
Description
Series/Report no.
ISSN
1366-8714