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Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis
Dahlan, Ahmad Faiz Shukri, Norasnieda Md Abdullah, Baharudin
Dahlan, Ahmad Faiz
Shukri, Norasnieda Md
Abdullah, Baharudin
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Epub Date
Issue Date
2024-04-22
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Abstract
The goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 18 studies, whereas the systematic review included 20 studies, totaling 3097 participants (1581 AR, 458 non-AR, and 1058 healthy/control). Patients with AR had significantly greater nNO levels than the control group, although this did not change significantly before or after treatment. AR patients had significantly greater nNO levels than non-AR patients, but there was no significant difference between non-AR patients and healthy controls. Nineteen of the studies were of high quality and the remaining one was of moderate quality. nNO measurement has a promising role in the management of AR and non-AR patients, but more investigations are needed to document clinical benefits.
Citation
Dahlan A.F., Islam M.A., Shukri N.M., et al. Nasal nitric oxide measurement in allergic rhinitis and nonallergic rhinitis: a meta-analysis. Acta Otorhinolaryngolica Italia 44 pp. 100-112
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Research Unit
PubMed ID
38651552 (pubmed)
PubMed Central ID
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Type
Journal article
Language
en
Description
© 2024 The Authors. Published by Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale. This is an open access
article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.14639/0392-100X-N2634
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ISSN
0392-100X
EISSN
1827-675X
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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International