Vitamin E correlates inversely with non-transferrin-bound iron in sickle cell disease.
Marwah, S.S. Wheelwright, D. Blann, A.D. Rea, C. Beresford, R. Phillips, Jonathan D. Wright, J. Bareford, D.
Marwah, S.S.
Wheelwright, D.
Blann, A.D.
Rea, C.
Beresford, R.
Phillips, Jonathan D.
Wright, J.
Bareford, D.
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Epub Date
Issue Date
2001
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Abstract
Decreased serum vitamin E levels are found in homozygous sickle cell disease (SCD). Excessive transfusions may lead high non-transferrin-bound iron (NTBI). Hypothesizing a relationship between the two, vitamin E (measured using high performance liquid chromatography) was significantly lower in 30 SCD patients than in 30 age-/sex-matched controls (P < 0.001), but NTBI (bleomycin assay) was higher (P < 0.001). Vitamin E was lower in 10 transfused patients than in 20 non-transfused patients (P < 0.001) with a significant inverse correlation between the NTBI and vitamin E (r = -0.58, P < 0.001). NTBI associated with iron overload in SCD may increase the potential for oxidative damage and low vitamin E activity may compound this effect.
Citation
British Journal of Haematology, 114(4): 917-919
Publisher
Journal
Research Unit
PubMed ID
11564086
PubMed Central ID
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Journal article
Language
en
Description
Series/Report no.
ISSN
0007-1048