Antioxidants and AP-1 activation: a brief overview.
Gómez del Arco, Pablo Martínez-Martínez, Sara Calvo, Victor Redondo, Juan Miguel
Gómez del Arco, Pablo
Martínez-Martínez, Sara
Calvo, Victor
Redondo, Juan Miguel
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Epub Date
Issue Date
1997
Submitted date
2007-01-24
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Abstract
Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.
Citation
Immunobiology, 198(1-3): 273-278
Publisher
Journal
Research Unit
DOI
PubMed ID
9442398
PubMed Central ID
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Type
Journal article
Language
en
Description
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ISSN
0171-2985