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Hematolological manifestations of COVID-19: From cytopenia to coagulopathy
Agbuduwe, Charles Basu, Supratik
Agbuduwe, Charles
Basu, Supratik
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2020-07-14
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Abstract
Emerging data from the management of patients with Coronavirus Disease 2019 (COVID‐19) suggests multisystemic involvement, including the hemopoietic system. The hematological manifestations of COVID‐19 include blood count anomalies notably lymphopenia and neutrophilia which are of prognostic significance. Hyperferritinemia and elevated lactate dehydrogenase have also been associated with increased mortality. Furthermore, there is considerable evidence of a distinct coagulopathy associated with COVID‐19 characterised by elevated D‐dimers and an increased risk of thrombotic events. This comprehensive review summarises the latest evidence from published studies and discusses the implications of the various hematological manifestations of COVID‐19 with a view to guiding clinical management and risk stratification in this rapidly evolving pandemic.
Citation
Agbuduwe, C. and Basu, S. (2020), Hematolological manifestations of COVID‐19: From cytopenia to coagulopathy. European Journal of Haematology 105, pp. 540– 546. https://doi.org/10.1111/ejh.13491.
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Journal article
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en
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This is an accepted manuscript of an article published by Wiley in European Journal of Haematology on 14/07/2020, available online: https://doi.org/10.1111/ejh.13491
The accepted version of the publication may differ from the final published version.
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0902-4441
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CA is a recipient of a clinical research fellowship funded by the CRUK-City of London Centre Clinical
Academic Training Programme Award [C355/A28852]