Loading...
Genomic epidemiology of clinical Campylobacter spp. at a single health trust site
Dunn, S.J. Pascoe, B. Turton, J. Fleming, V. Diggle, M. Sheppard, S.K. McNally, A. Manning, G.
Dunn, S.J.
Pascoe, B.
Turton, J.
Fleming, V.
Diggle, M.
Sheppard, S.K.
McNally, A.
Manning, G.
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2018-10-11
Submitted date
Alternative
Abstract
Campylobacter is the leading cause of bacterial enteritis in the developed world, and infections with the organism are largely sporadic in nature. Links between sporadic cases have not been established, with the majority of infections thought to be caused by genetically distinct isolates. Using a read-mapping approach, 158 clinical isolates collected during 2014 from the greater Nottinghamshire area were analysed to assess the local population structure and investigate potential case linkages between sporadic cases of campylobacteriosis. Four instances (2.5 %) of case linkage were observed across the dataset. This study demonstrates that case linkage does occur between sporadic Campylobacter infections, and provides evidence that a dual multi-locus sequence typing/within-lineage single nucleotide polymorphism typing approach to Campylobacter genomic epidemiology provides a benefit to public-health investigations.
Citation
Dunn, S., Pascoe, B., Turton, J., Fleming, V., Diggle, M., Sheppard, S., McNally, A. and Manning, G. (2018) 'Genomic epidemiology of clinical Campylobacter spp. at a single health trust site,' 4 (10) doi: 10.1099/mgen.0.000227
Publisher
Journal
Research Unit
PubMed ID
PubMed Central ID
Embedded videos
Type
Journal article
Language
en
Description
© 2018 The Authors. Published by Microbiology Society. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1099/mgen.0.000227
Series/Report no.
ISSN
2057-5858
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
Nottingham Trent University
Rights
Attribution-NonCommercial-NoDerivs 3.0 United States