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Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans
Kenward, M A Hill, D J Martin, C Low, Wan Li
Kenward, M A
Hill, D J
Martin, C
Low, Wan Li
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2016-01-20
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Abstract
Liposomes are biocompatible, biodegradable, controlled delivery systems with the ability to encapsulate both lipophilic and hydrophilic compounds, including metal ions. Liposome encapsulated Ag(+) (lipo-Ag(+)), prepared by reverse-phase evaporation, was used as a controlled delivery system against Candida albicans. Characterisation of the lipo-Ag(+) indicated that the multilamellar vesicles with diameters ranging between ≈ 0.5 and 5.0 μm showed potential as a controlled delivery system to consistently deliver Ag(+) to C. albicans. Results from inductively coupled plasma (ICP) analysis showed higher association of cell bound Ag(+) at 15 mins post exposure when compared to unencapsulated Ag(+). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicate detrimental effects of Ag(+) on C. albicans cell structure. These effects along with the ICP results also correlate with previously reported time kill experiment observations.
Citation
Low et al. (2016) Characterisation and in vitro antimicrobial potential of liposome encapsulated silver ions against Candida albicans. Journal of Microencapsulation, 33 (2), pp. 146-52.
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PubMed ID
26786597
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Journal article
Language
en
Description
This is an accepted manuscript of an article published by Taylor & Francis in Journal of Microencapsulation on 20/01/2016, available online: https://doi.org/10.3109/02652048.2015.1134692
The accepted version of the publication may differ from the final published version.
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1464-5246