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Immunomodulatory effects of diet and nutrients in systemic lupus erythematosus (SLE): A systematic review
Khandker, Shahad Saif Kotyla, Przemysław J. Hassan, Rosline
Khandker, Shahad Saif
Kotyla, Przemysław J.
Hassan, Rosline
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Other contributors
Epub Date
Issue Date
2020-07-22
Submitted date
Subjects
Alternative
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the haematopoietic system, with a large number of complications. Despite years of study, the etiology of SLE remains unclear; thus, safe and specifically targeted therapies are lacking. In the last 20 years, researchers have explored the potential of nutritional factors on SLE and have suggested complementary treatment options through diet. This study systematically reviews and evaluates the clinical and preclinical scientific evidence of diet and dietary supplementation that either alleviate or exacerbate the symptoms of SLE. For this review, a systematic literature search was conducted using PubMed, Scopus and Google Scholar databases only for articles written in the English language. Based on the currently published literature, it was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrients to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.
Citation
Islam MA, Khandker SS, Kotyla PJ and Hassan R (2020) Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review. Front. Immunol. 11:1477. doi: 10.3389/fimmu.2020.01477
Publisher
Journal
Research Unit
PubMed ID
32793202 (pubmed)
PubMed Central ID
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Type
Journal article
Language
en
Description
© 2020 The Authors. Published by Frontiers SA. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website:
https://doi.org/10.3389/fimmu.2020.01477
Series/Report no.
ISSN
1664-3224
EISSN
1664-3224
ISBN
ISMN
Gov't Doc #
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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Rights
Licence for published version: Creative Commons Attribution 4.0 International