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Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges
Howroyd, Fiona MacDuff, Andrew Gautam, Nandan Pouchet, Brian Tunnicliffe, Bill Weblin, Jonathan Gao-Smith, Fang Ahmed, Zubair Duggal, Niharika A
Howroyd, Fiona
MacDuff, Andrew
Gautam, Nandan
Pouchet, Brian
Tunnicliffe, Bill
Weblin, Jonathan
Gao-Smith, Fang
Ahmed, Zubair
Duggal, Niharika A
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Epub Date
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2024-07-31
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Abstract
Ventilator-associated pneumonia (VAP) affects up to 20% of critically ill patients and induces significant antibiotic prescription pressure, accounting for half of all antibiotic use in the ICU. VAP significantly increases hospital length of stay and healthcare costs yet is also associated with long-term morbidity and mortality. The diagnosis of VAP continues to present challenges and pitfalls for the currently available clinical, radiological and microbiological diagnostic armamentarium. Biomarkers and artificial intelligence offer an innovative potential direction for ongoing future research. In this Review, we summarise the pathobiological heterogeneity and diagnostic challenges associated with VAP.
Citation
Howroyd, F., Chacko, C., MacDuff, A. et al. Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges. Nat Commun 15, 6447 (2024). https://doi.org/10.1038/s41467-024-50805-z
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PubMed ID
39085269 (pubmed)
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Journal article
Language
en
Description
© 2024 The Authors. Published by Nature Publishing Group. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1038/s41467-024-50805-z
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ISSN
2041-1723
EISSN
2041-1723
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Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International