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Enhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkers
Georgakouli, K Manthou, E Fatouros, IG Georgoulias, P Deli, CK Koutedakis, Y Theodorakis, Y Jamurtas, AZ
Georgakouli, K
Manthou, E
Fatouros, IG
Georgoulias, P
Deli, CK
Koutedakis, Y
Theodorakis, Y
Jamurtas, AZ
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Epub Date
Issue Date
2017-12-02
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Abstract
© 2017 Elsevier Inc. Alcohol-induced oxidative stress is involved in the development and progression of various pathological conditions and diseases. On the other hand, exercise training has been shown to improve redox status, thus attenuating oxidative stress-associated disease processes. The purpose of the present study was to evaluate the effect of an exercise training program that has been previously reported to decrease alcohol consumption on blood redox status in heavy drinkers. In a non-randomized within-subject design, 11 sedentary, heavily drinking men (age: 30.3 ± 3.5 years; BMI: 28.4 ± 0.86 kg/m2) participated first in a control condition for 4 weeks, and then in an intervention where they completed an 8-week supervised aerobic training program of moderate intensity (50–60% of the heart rate reserve). Blood samples were collected in the control condition (pre-, post-control) as well as before, during (week 4 of the training program), and after intervention (week 8 of the training program). Samples were analyzed for total antioxidant capacity (TAC), thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), uric acid (UA), bilirubin, reduced glutathione (GSH), and catalase activity. No significant change in indices of redox status in the pre- and post-control was observed. Catalase activity increased (p < 0.05) after 8 weeks of intervention compared to week 4. GSH increased (p < 0.05) after 8 weeks of intervention compared to the control condition and to week 4 of intervention. TAC, UA, bilirubin, TBARS, and PC did not significantly change at any time point. Moreover, concentrations of GSH, TBARS, and catalase activity negatively correlated with alcohol consumption. In conclusion, an 8-week aerobic training program enhanced erythrocyte antioxidant status in heavy drinkers, indicating that aerobic training may attenuate pathological processes caused by alcohol-induced oxidative stress.
Citation
Georgakouli, A. (2018) Enhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkers, Alcohol, 69 (June 2018), pp. 57-62.
Publisher
Journal
Research Unit
PubMed ID
29653379
PubMed Central ID
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Type
Journal article
Language
en
Description
This is an accepted manuscript of an article published by Elsevier BV in Alcohol on 02/12/2017, available online: https://doi.org/10.1016/j.alcohol.2017.11.035
The accepted version of the publication may differ from the final published version.
Series/Report no.
ISSN
0741-8329
EISSN
1873-6823
ISBN
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Gov't Doc #
Sponsors
This study was co-financed by the European Union [European Social Fund (ESF)] and Greek national funds through the Operational Program ‘Education and Lifelong Learning’ of the National Strategic Reference Framework-Research Funding Program: THALES. Investing in knowledge society through the ESF.