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The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins
Palframan, MJ Pattenden, G
Palframan, MJ
Pattenden, G
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2018-07-06
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Abstract
© 2019 The Royal Society of Chemistry. Covering: up to May 2018 The verticillene family of 6,12-membered ring-fused diterpenes are found in plants, liverworts, corals and insects. Carbocations derived from verticillene hydrocarbons are central intermediates in the biosynthesis of the taxane and the phomactin families of polycyclic natural products. This perspective delineates these unique biosynthetic interrelationships, which are reinforced by recent biomimetic synthesis investigations, alongside quantum chemical calculations and targeted engineering studies of the taxadiene synthase (TXS) cascade.
Citation
Palframan, M. J. and Pattenden, G. (2018) The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins, Natural Product Reports, 2019(36), pp. 108-121.
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Research Unit
PubMed ID
29978865
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Journal article
Language
en
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ISSN
0265-0568
EISSN
1460-4752