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Stability of oct and octa in the intensive therapy unit setting
Courtie, Ella F Kale, Aditya U Hui, Benjamin T K Liu, Xiaoxuan Capewell, Nicholas I Bishop, Jonathan R B Whitehouse, Tony Logan, Ann Denniston, Alastair K
Courtie, Ella F
Kale, Aditya U
Hui, Benjamin T K
Liu, Xiaoxuan
Capewell, Nicholas I
Bishop, Jonathan R B
Whitehouse, Tony
Logan, Ann
Denniston, Alastair K
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2021-08-23
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Abstract
To assess the stability of retinal structure and blood flow measures over time and in different clinical settings using portable optical coherence tomography angiography (OCTA) as a potential biomarker of central perfusion in critical illness, 18 oesophagectomy patients completed retinal structure and blood flow measurements by portable OCT and OCTA in the eye clinic and intensive therapy unit (ITU) across three timepoints: (1) pre-operation in a clinic setting; (2) 24–48 h post-operation during ITU admission; and (3) seven days post-operation, if the patient was still admitted. Blood flow and macular structural measures were stable between the examination settings, with no consistent variation between pre-and post-operation scans, while retinal nerve fibre layer thickness increased in the post-operative scans (+2.31 µm, p = 0.001). Foveal avascular zone (FAZ) measurements were the most stable, with an intraclass correlation coefficient of up to 0.92 for right eye FAZ area. Blood flow and structural measures were lower in left eyes than right eyes. Retinal blood flow assessed in patients before and during an ITU stay using portable OCTA showed no systematic differences between the clinical settings. The stability of retinal blood flow measures suggests the potential for portable OCTA to provide clinically useful measures in ITU patients.
Citation
Courtie, E. F., Kale, A. U., Hui, B. T. K., Liu, X., Capewell, N. I., Bishop, J. R. B., Whitehouse, T., Veenith, T., Logan, A., Denniston, A. K., & Blanch, R. J. (2021). Stability of OCT and OCTA in the Intensive Therapy Unit Setting. Diagnostics, 11(8), 1516. https://doi.org/10.3390/diagnostics11081516
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Research Unit
PubMed ID
34441449 (pubmed)
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Journal article
Language
en
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© 2021 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/diagnostics11081516
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2075-4418
EISSN
2075-4418
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This project was funded by the National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre (SRMRC).
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Licence for published version: Creative Commons Attribution 4.0 International