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Biological properties of low-toxicity PLGA and PLGA/PHB fibrous nanocomposite implants for osseous tissue regeneration. Part I: evaluation of potential biotoxicity
Krucińska, Izabella Żywicka, Bogusława Komisarczyk, Agnieszka Szymonowicz, Maria Kowalska, Stanisława Zaczyńska, Ewa Struszczyk, Marcin Czarny, Anna Jadczyk, Piotr Umińska-Wasiluk, Barbara
Krucińska, Izabella
Żywicka, Bogusława
Komisarczyk, Agnieszka
Szymonowicz, Maria
Kowalska, Stanisława
Zaczyńska, Ewa
Struszczyk, Marcin
Czarny, Anna
Jadczyk, Piotr
Umińska-Wasiluk, Barbara
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2017-11-29
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Abstract
In response to the demand for new implant materials characterized by high biocompatibility and bioresorption, two prototypes of fibrous nanocomposite implants for osseous tissue regeneration made of a newly developed blend of poly(L-lactide-co-glycolide) (PLGA) and syntheticpoly([R,S]-3-hydroxybutyrate), PLGA/PHB, have been developed and fabricated. Afibre-forming copolymer of glycolide and L-lactide (PLGA) was obtained by a unique method of synthesis carried out in blocksusing Zr(AcAc)4 as an initiator. The prototypes of the implants are composed of three layers of PLGA or PLGA/PHB, nonwoven fabrics with a pore structure designed to provide the best conditions for the cell proliferation. The bioactivity of the proposed implants has been imparted by introducing a hydroxyapatite material and IGF1, a growth factor. The developed prototypes of implants have been subjected to a set of in vitro and in vivobiocompatibility tests: in vitro cytotoxic effect, in vitro genotoxicity and systemic toxicity. Rabbitsshowed no signs of negative reactionafter implantation of the experimental implant prototypes.
Citation
Krucińska I., Żywicka B., Komisarczyk A., Szymonowicz M., Kowalska S., Zaczyńska E., Struszczyk M., Czarny A., Jadczyk P., Umińska-Wasiluk B., Rybak Z., Kowalczuk M. (2017) 'Biological Properties of Low-Toxicity PLGA and PLGA/PHB Fibrous Nanocomposite Implants for Osseous Tissue Regeneration. Part I: Evaluation of Potential Biotoxicity' Molecules 22 (12) 2092
doi: 10.3390/molecules22111852
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Journal article
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en
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© 2017 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence.
The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/molecules22122092
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1420-3049