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Browning formation markers of subcutaneous adipose tissue in relation to resting energy expenditure, physical activity and diet in humans
Dinas, PC Valente, A Granzotto, M Rossato, M Vettor, R Zacharopoulou, A Carrillo, AE Davies, NA Gkiata, P Jamurtas, AZ
Dinas, PC
Valente, A
Granzotto, M
Rossato, M
Vettor, R
Zacharopoulou, A
Carrillo, AE
Davies, NA
Gkiata, P
Jamurtas, AZ
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2017-07-05
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Abstract
© 2017 Walter de Gruyter GmbH, Berlin/Boston. Regular exercise and diet may contribute to white adipose tissue (WAT) conversion into a brown adipose-like phenotype that may increase resting energy expenditure (REE), leading to weight loss. We examined the relationship between REE, physical activity (PA) participation and diet with browning formation markers of subcutaneous WAT in healthy men. We assessed REE, diet and body composition of 32 healthy men [age (years): 36.06 ± 7.36, body mass index (BMI): 27.06 ± 4.62 (kg/m 2 )]. Participants also underwent measurements of PA [metabolic equivalent (MET)-min/week] using the International Physical Activity Questionnaire (IPAQ), while they undertook a subcutaneous fat biopsy from the abdominal region to assess the mRNA expressions of uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), peroxisome proliferator-activated receptor alpha (PPARα) and peroxisome proliferator-activated receptor gamma (PPARγ). We found no associations between the UCP1, PGC-1α, PPARα and PPARγ mRNAs with REE, PA levels and diet (p > 0.05). However, the PGC-1α, PPARα and PPARγ mRNAs were more expressed in individuals displaying moderate rather than low PA levels (p < 0.05). Furthermore, PGC-1α, PPARα and PPARγ mRNAs were negatively correlated with fat mass percentage (p < 0.05). PGC-1α and PPARα mRNAs were also negatively correlated with BMI, while PGC-1α mRNA was inversely associated with waist-to-hip ratio (p < 0.05). REE, PA levels and diet are not associated with browning formation indices of subcutaneous adipose tissue in healthy adult men.
Citation
Dinas, P. C. et al. (2017) Browning formation markers of subcutaneous adipose tissue in relation to resting energy expenditure, physical activity and diet in humans, Hormone Molecular Biology and Clinical Investigation, 31(1), DOI: https://doi.org/10.1515/hmbci-2017-0008.
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Research Unit
PubMed ID
28678735
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Journal article
Language
en
Description
This is an accepted manuscript of an article published by De Gruyter in Hormone Molecular Biology and Clinical Investigation on 05/07/2017, available online: https://www.degruyter.com/document/doi/10.1515/hmbci-2017-0008/html
The accepted version of the publication may differ from the final published version.
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ISSN
1868-1883
EISSN
1868-1891
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Sponsors
This study was supported by funding from the European Union 7th Framework Program (FP7-PEOPLE-2012-IRSES grant 319010; FP7-PEOPLE-2013-IRSES grant 612547). A.V. was supported by funding from the Education and Lifelong Learning Programme of the Greek Ministry of Education, Co-financed by Greece and the European Union (NSRF 2007–2013, IRAKLITOS II, grant 162).