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Synthesis and structural characterization of bioactive PHA and γ-PGA oligomers for potential applications as a delivery system
Kwiecień, Iwona Kwiecień, Michał Adamus, Grazyna Radecka, Iza
Kwiecień, Iwona
Kwiecień, Michał
Adamus, Grazyna
Radecka, Iza
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2016-04-25
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Abstract
The (trans)esterification reaction of bacterial biopolymers with a selected bioactive compound with a hydroxyl group was applied as a convenient method for obtaining conjugates of such compound. Tyrosol, a naturally occurring phenolic compound, was selected as a model of a bioactive compound with a hydroxyl group. Selected biodegradable polyester and polyamide, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) and poly-γ-glutamic acid (γ-PGA), respectively, were used. The (trans)esterification reactions were carried out in melt mediated by 4-toluenesulfonic acid monohydrate. The structures of (trans)esterification products were established at the molecular level with the aid of ESI-MS2 (electrospray ionization tandem mass spectrometry) and/or 1H NMR (nuclear magnetic resonance) techniques. Performed analyses confirmed that the developed method leads to the formation of conjugates in which bioactive compounds are covalently bonded to biopolymer chains. The amount of covalently bonded bioactive compounds in the resulting conjugates depends on the type of biopolymers applied in synthesis.
Citation
Kwiecień, I., Kwiecień, M., Adamus, G., and Radecka, I. (2016) 'Synthesis and Structural Characterization of Bioactive PHA and γ-PGA Oligomers for Potential Applications as a Delivery System', Materials, 9 (5) doi: 10.3390/ma9050307
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Journal article
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en
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1996-1944