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Impacts of depression subcase and case on all-cause mortality in older people: The findings from the multi-centre community-based cohort study in China
Chen, R Zhou, W Ma, Y Wan, Y Qin, X Rodney, A Ni, J Thomas, E Gao, J Spira, AP
Chen, R
Zhou, W
Ma, Y
Wan, Y
Qin, X
Rodney, A
Ni, J
Thomas, E
Gao, J
Spira, AP
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2021-08-23
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Abstract
Objectives: It is unclear whether and to what extent depression subcases and cases in older age were associated with all-cause mortality. Little is known about gender differences in the associations. We assess these in older Chinese. Methods: We examined a random sample of 6124 participants aged ≥60 years across five provinces in China. They were interviewed using a standard method of the GMS-AGECAT to diagnose depression subcase and case and record sociodemographic and disease risk factors at baseline, and to follow up their vital status. We employed Cox regression models to determine all-cause mortality in relation to depression subcases and cases, with adjustment for important variables, including social support and co-morbidities. Results: Over the 10-year follow-up, 928 deaths occurred. Compared to those without depression at baseline, participants with depression subcase (n = 196) and case (n = 264) had increased risk of mortality; adjusted hazard ratios (HRs) were 1.46 (95% CI 1.07–2.00) and 1.45 (1.10–1.91). The adjusted HRs in men were 1.15 (0.72–1.81) and 1.85 (1.22–2.81), and in women 1.87 (1.22–2.87) and 1.22 (0.83–1.77) respectively. In participants aged ≥65 years, the adjusted HRs were 1.12 (0.68–1.84) and 1.99 (1.28–3.10) in men, and 2.06 (1.32–2.24) and 1.41 (0.94–2.10) in women. Increased HR in depression subcases was higher in women than man (ratio of HRs was 1.84, p = 0.034). Conclusions: Older people with depression subcase could have increased all-cause mortality to a similar extent to those with depression case. More attention should be paid to subcases of depression in women to tackle gender inequalities and improve survival.
Citation
Chen, R., Zhou, W., Ma, Y. et al. (2021) Impacts of depression subcase and case on all-cause mortality in older people: The findings from the multi-centre community-based cohort study in China. International Journal of Geriatric Psychiatry, 2021(36), pp. 1931–1941
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34390042 (pubmed)
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Journal article
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en
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This is an accepted manuscript of an article published by Wiley in International Journal of Geriatric Psychiatry on 23/08/2021, available online: https://doi.org/10.1002/gps.5611
The accepted version of the publication may differ from the final published version.
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0885-6230
EISSN
1099-1166
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Professor Ruoling Chen- EU grant from Horizon 2020 MSCA—DEMAIRPO #799247. The data collection of the two cohort studies were funded by the Royal Society of UK, the BUPA Foundation (Grants Nos. 45NOV06, and TBF‐M09‐05) and Alzheimer's Research UK (Grant No. ART/PPG2007B/2).