Thumbnail Image
Item

Synthesis of triazole-linked morpholino oligonucleotides via Cu<sup>I</sup> catalysed cycloaddition

Palframan, MJ
; 
Alharthy, RD
; 
Powalowska, PK
; 
Hayes, CJ
Authors
Palframan, MJ
 Alharthy, RD
 Powalowska, PK
 Hayes, CJ
Editors
Other contributors
Affiliation
Epub Date
Issue Date
2016-02-16
Submitted date
Subjects
copper
 Triazoles
 DNA
 Base Sequence
 Nucleic Acid Denaturation
 Catalysis
 Morpholinos
 Solid-Phase Synthesis Techniques
 Cycloaddition Reaction
Show all metadata
Files
Thumbnail Image
OBC morpholino - CC license.pdf
Adobe PDF, 741 KB
Alternative
Abstract
© The Royal Society of Chemistry 2016. Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification.
Citation
Palframan, M. J., Alharthy, R. D., Powalowska, P. K. and Hayes, C. J. (2016) Synthesis of triazole-linked morpholino oligonucleotides via Cu<sup>I</sup> catalysed cycloaddition, Organic and Biomolecular Chemistry, 14, pp. 3112–3119.
Publisher
Royal Society of Chemistry (RSC)
Journal
Organic and Biomolecular Chemistry
Research Unit
URI
http://hdl.handle.net/2436/623043
DOI
10.1039/c6ob00007j
PubMed ID
26905296
PubMed Central ID
Embedded videos
Additional Links
https://pubs.rsc.org/en/content/articlelanding/2016/OB/C6OB00007J#!divAbstract
Type
Journal article
Language
en
Description
Series/Report no.
ISSN
1477-0520
EISSN
1477-0539
ISBN
ISMN
Gov't Doc #
Sponsors
King Abdulaziz University, Saudi Arabia (Scholarship to R. D. A.) and the BBSRC (DTP Scholarship for P. K. P.)
Rights
Licence for published version: Creative Commons Attribution 4.0 International
cb
Research Projects
Organizational Units
Journal Issue
Embedded videos
Collections
Faculty of Science and Engineering