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Identification and molecular mechanisms of the rapid tonicity-induced relocalization of the aquaporin 4 channel
Kitchen, P Day, RE Taylor, LHJ Salman, MM Bill, RM Conner, Matthew T. Conner, Alex C.
Kitchen, P
Day, RE
Taylor, LHJ
Salman, MM
Bill, RM
Conner, Matthew T.
Conner, Alex C.
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2015-05-26
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Abstract
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: The water channel protein aquaporin 4 (AQP4) controls water permeability of the blood-brain barrier. Results: Hypotonicity induces rapid relocalization of AQP4 in a calcium-, calmodulin-, and kinase-dependent manner. Conclusion: AQP4 can be relocalized between the cell membrane and intracellular compartments. Significance: Pharmacological modulation of AQP4 membrane localization could provide a new approach to treating brain edema.
Citation
Kitchen, P., Day, R. E., Taylor, L. H. J., Salman, M. M., Bill, R. M., Conner, M. T. and Conner, A. C. (2015) Identification and molecular mechanisms of the rapid tonicity-induced relocalization of the aquaporin 4 channel, Journal of Biological Chemistry, 290(27), pp. 16873-16881.
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26013827
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Journal article
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en
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1083-351X
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This work was supported by the Engineering and Physical Sciences Research Council through the Molecular Organisation and Assembly in Cells Doctoral Training Centre, University of Warwick, Grant EP/F500378/1 (to P. K. and L. H. J. T.).
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Licence for published version: Creative Commons Attribution 4.0 International