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Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression
Griffen, Corbin Duncan, Michael Tallis, Jason Renshaw, Derek Hattersley, John
Griffen, Corbin
Duncan, Michael
Tallis, Jason
Renshaw, Derek
Hattersley, John
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Issue Date
2020-02-13
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Abstract
Background: Morphological changes of the lumbar spine muscles are not well characterised with ageing. To further the understanding of age-related degeneration of the lumbar spine musculature, normative morphological changes that occur within the paravertebral muscles must first be established. Methods: A systematic review and meta-regressions were conducted adhering to PRISMA guidelines. Searches for published and unpublished data were completed in June 2019. Results: Searches returned 4781 articles. 34 articles were included in the quantitative analysis. Three-level meta-analyses showed age-related atrophy (r = −0.26; 95% CI: −0.33, −0.17) and fat infiltration (r = 0.39; 95% CI: 0.28, 0.50) in the lumbar paravertebral muscles. Degenerative changes were muscle-specific and men (r = −0.32; 95% CI: −0.61, 0.01) exhibited significantly greater muscle atrophy than women (r = −0.24; 95% CI: −0.47, 0.03). Imaging modality, specifically ultrasound, also influenced age-related muscle atrophy. Measurements taken across all lumbar levels revealed the greatest fat infiltration with ageing (r = 0.58, 95% CI: 0.35, 0.74). Moderators explained a large proportion of between-study variance in true effects for muscle atrophy (72.6%) and fat infiltration (79.8%) models. Conclusions: Lumbar paravertebral muscles undergo age-related degeneration in healthy adults with muscle, lumbar level and sex-specific responses. Future studies should use high-resolution imaging modalities to quantify muscle atrophy and fat infiltration.
Citation
Dallaway, A., Kite, C., Griffen, C. et al. (2020) Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression. Experimental Gerontology, 133, 110856.
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Journal
Research Unit
PubMed ID
32006635 (pubmed)
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Journal article
Language
en
Description
This is an author's accepted manuscript of an article published by Elsevier in Experimental Gerontology, available online: https://doi.org/10.1016/j.exger.2020.110856 The accepted manuscript may differ from the final published version.
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ISSN
EISSN
1873-6815
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Sponsors
AD was funded supported Coventry University and University Hospitals Coventry and Warwickshire. This research was carried out with the support of the National Institute of Health Research (NIHR) Coventry and Warwickshire Clinical Research Facility.