Effect of drug solubility and accelerated ageing on drug release from polyethylene oxide matrices
Shojaee S, Kaialy, Waseem, Nokhodchi A, Cumming, I
Shojaee S, Kaialy, Waseem, Nokhodchi A, Cumming, I
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2014
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The solubility of drug had a big impact on stability of drug release from aged polyox matrices. Aged matrices containing highly soluble drug (propranolol HCl) showed a higher sensitivity of drug release against storage time compared to a poorly water-soluble drugs leading to fast drug release.
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Working paper
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en