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Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells
Sherer, Christopher Tolaymat, Ibrahim Rowther, Farzana Warr, Tracy Snape, Timothy J
Sherer, Christopher
Tolaymat, Ibrahim
Rowther, Farzana
Warr, Tracy
Snape, Timothy J
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Issue Date
2017-02-17
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Abstract
The prognosis for glioblastoma patients is, at best, poor, with the median time of survival after diagnosis measured in months. As such, there is much need for the rapid development of potent and novel treatments. Herein, we report our preliminary findings on the SAR of a series of indole-3-carbinol and related fragments and reveal a potent lead with low micromolar activity against a particularly resistant glioblastoma cell culture, providing a new platform for future development of a new therapy in this area.
Citation
Sherer C., Tolaymat I., Rowther F., Warr T., Snape TJ. (2017) 'Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells', Bioorganic & Medicinal Chemistry Letters, 27 (7) pp. 1561-1565
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Research Unit
PubMed ID
28256372
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Journal article
Language
en
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Series/Report no.
ISSN
0960-894X