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Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study
Patel, Mitesh Nigmatullina, Y Seemungal, BM Golding, JF Bronstein, AM
Patel, Mitesh
Nigmatullina, Y
Seemungal, BM
Golding, JF
Bronstein, AM
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2013-12-21
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Abstract
Background: The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function. Methods: We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5°/s2) and (2) suprathreshold responses to velocity steps of 90°/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured. Results: Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent.
Citation
Patel, M., Nigmatullina, Y., Seemungal, B. M., Golding, J. F., et al. (2014) Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study. Audiology and Neurotology, 19(2) pp.91-96. DOI: 10.1159/000357028
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Journal article
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en
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This is an accepted manuscript of an article published by Karger Publishers in Audiology and Neurotology on 21 December 2013, available online: https://doi.org/10.1159/000357028
The accepted version of the publication may differ from the final published version.
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1420-3030
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1421-9700
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This work was generously supported by an MRC grant to A.M.B. (MC_U950770497). MP is funded by the Meniere’s Society, UK.