Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.
Warr, Tracy Ward, Samantha Burrows, J. Harding, Brian Wilkins, Peter Harkness, William Hayward, Richard Darling, John L. Thomas, David G.
Warr, Tracy
Ward, Samantha
Burrows, J.
Harding, Brian
Wilkins, Peter
Harkness, William
Hayward, Richard
Darling, John L.
Thomas, David G.
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2001
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Abstract
Although astrocytomas are the most common central nervous system tumours in all age groups, there is substantial evidence that tumours arising in young patients (< 25 years of age) do not have the same genetic abnormalities that are characteristic of tumours in older patients. Furthermore, novel, consistent changes have not been identified in astrocytomas in children and young adults. We analysed 13 malignant astrocytomas from young patients using comparative genomic hybridisation. Regions of genomic imbalance were identified in 10 cases. The most common recurrent copy number aberrations were loss of 16p (54% of cases), 17p (38%), 19p (38%), and 22 (38%) and gain on 2q (38%), 12q (38%), 13 (38%), 4q (31%), 5q (31%), and 8q (31%). Seven regions of high copy number amplification were observed at 8q21-22 (three cases), 7q22-23 (two cases), and 1p21-22, 2q22, 12q13-pter, 12q15-21, and 13q11-14 (one case each). This study provides evidence of new characteristic chromosomal imbalances from which potential candidate genes involved in the development of malignant astrocytoma in children and young adults may be identified.
Citation
Genes, Chromosomes and Cancer, 31(1): 15-22
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PubMed ID
11284031
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Journal article
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en
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1045-2257