Heterogeneity of viral IL-6 expression in HHV-8-associated diseases.
dc.contributor.author | Cannon, Jennifer S. | |
dc.contributor.author | Nicholas, John | |
dc.contributor.author | Orenstein, Jan M. | |
dc.contributor.author | Mann, Risa B. | |
dc.contributor.author | Murray, Paul G. | |
dc.contributor.author | Browning, Philip J. | |
dc.contributor.author | DiGiuseppe, Joseph A. | |
dc.contributor.author | Cesarman, Ethel | |
dc.contributor.author | Hayward, Gary S. | |
dc.contributor.author | Ambinder, Richard F. | |
dc.date.accessioned | 2007-01-23T14:55:02Z | |
dc.date.available | 2007-01-23T14:55:02Z | |
dc.date.issued | 1999 | |
dc.date.submitted | 2007-01-19 | |
dc.identifier.citation | Journal of Infectious Diseases, 180(3): 824-828 | |
dc.identifier.issn | 0022-1899 | |
dc.identifier.pmid | 10438372 | |
dc.identifier.doi | 10.1086/314956 | |
dc.identifier.uri | http://hdl.handle.net/2436/7691 | |
dc.description.abstract | In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases. | |
dc.format.extent | 900404 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.publisher | University of Chicago Press | |
dc.relation.url | http://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchenginehttp://www.journals.uchicago.edu/doi/abs/10.1086/314956 | |
dc.subject | Viral interleukin-6 (vIL-6) homologue | |
dc.subject | Human herpesvirus 8 | |
dc.subject | HHV-8 | |
dc.title | Heterogeneity of viral IL-6 expression in HHV-8-associated diseases. | |
dc.type | Journal article | |
dc.format.dig | YES | |
refterms.dateFOA | 2018-08-20T13:07:56Z | |
html.description.abstract | In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases. |