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dc.contributor.authorCannon, Jennifer S.
dc.contributor.authorNicholas, John
dc.contributor.authorOrenstein, Jan M.
dc.contributor.authorMann, Risa B.
dc.contributor.authorMurray, Paul G.
dc.contributor.authorBrowning, Philip J.
dc.contributor.authorDiGiuseppe, Joseph A.
dc.contributor.authorCesarman, Ethel
dc.contributor.authorHayward, Gary S.
dc.contributor.authorAmbinder, Richard F.
dc.date.accessioned2007-01-23T14:55:02Z
dc.date.available2007-01-23T14:55:02Z
dc.date.issued1999
dc.date.submitted2007-01-19
dc.identifier.citationJournal of Infectious Diseases, 180(3): 824-828
dc.identifier.issn0022-1899
dc.identifier.pmid10438372
dc.identifier.doi10.1086/314956
dc.identifier.urihttp://hdl.handle.net/2436/7691
dc.description.abstractIn order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.
dc.format.extent900404 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherUniversity of Chicago Press
dc.relation.urlhttp://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchenginehttp://www.journals.uchicago.edu/doi/abs/10.1086/314956
dc.subjectViral interleukin-6 (vIL-6) homologue
dc.subjectHuman herpesvirus 8
dc.subjectHHV-8
dc.titleHeterogeneity of viral IL-6 expression in HHV-8-associated diseases.
dc.typeJournal article
dc.format.digYES
refterms.dateFOA2018-08-20T13:07:56Z
html.description.abstractIn order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.


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