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    Heterogeneity of viral IL-6 expression in HHV-8-associated diseases.

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    Authors
    Cannon, Jennifer S.
    Nicholas, John
    Orenstein, Jan M.
    Mann, Risa B.
    Murray, Paul G.
    Browning, Philip J.
    DiGiuseppe, Joseph A.
    Cesarman, Ethel
    Hayward, Gary S.
    Ambinder, Richard F.
    Issue Date
    1999
    Submitted date
    2007-01-19
    
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    Abstract
    In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.
    Citation
    Journal of Infectious Diseases, 180(3): 824-828
    Publisher
    University of Chicago Press
    URI
    http://hdl.handle.net/2436/7691
    DOI
    10.1086/314956
    PubMed ID
    10438372
    Additional Links
    http://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchenginehttp://www.journals.uchicago.edu/doi/abs/10.1086/314956
    Type
    Journal article
    Language
    en
    ISSN
    0022-1899
    ae974a485f413a2113503eed53cd6c53
    10.1086/314956
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