Heterogeneity of viral IL-6 expression in HHV-8-associated diseases.
Authors
Cannon, Jennifer S.Nicholas, John
Orenstein, Jan M.
Mann, Risa B.
Murray, Paul G.
Browning, Philip J.
DiGiuseppe, Joseph A.
Cesarman, Ethel
Hayward, Gary S.
Ambinder, Richard F.
Issue Date
1999Submitted date
2007-01-19
Metadata
Show full item recordAbstract
In order to characterize the expression of the viral interleukin-6 (vIL-6) homologue in various human herpesvirus 8 (HHV-8)-associated diseases, in situ hybridization and immunohistochemistry were applied to formalin-fixed specimens. These assays showed consistent expression of vIL-6 in primary effusion lymphomas and in a case of human immunodeficiency virus (HIV)-associated lymphadenopathy with a Castleman's disease-like appearance. In contrast, Kaposi's sarcoma specimens showed marked differences among specimens. In a consecutive series of specimens from the Johns Hopkins archives, vIL-6 expression was demonstrated in one of 13 cases. However, among 7 specimens selected from the AIDS Malignancy Bank because of their high levels of the T1.1 lytic transcript and virion production, vIL-6 expression was consistently demonstrated in infiltrating mononuclear cells and occasional spindle-shaped cells. Thus vIL-6 expression in clinical specimens correlates with other measures of the lytic viral cycle. Both assays generally give congruent results and are consistent with the possibility that vIL-6 expression plays a role in the pathogenesis of a variety of HHV-8-associated diseases.Citation
Journal of Infectious Diseases, 180(3): 824-828Publisher
University of Chicago PressDOI
10.1086/314956PubMed ID
10438372Additional Links
http://direct.bl.uk/bld/PlaceOrder.do?UIN=066360015&ETOC=RN&from=searchenginehttp://www.journals.uchicago.edu/doi/abs/10.1086/314956Type
Journal articleLanguage
enISSN
0022-1899ae974a485f413a2113503eed53cd6c53
10.1086/314956