Show simple item record

dc.contributor.authorCurrie, James
dc.contributor.authorRamsbottom, Roger
dc.contributor.authorLudlow, Helen
dc.contributor.authorNevill, Alan M.
dc.contributor.authorGilder, Michael
dc.date.accessioned2009-07-21T14:23:04Z
dc.date.available2009-07-21T14:23:04Z
dc.date.issued2009
dc.identifier.citationNeuroscience Letters 451 (2009) 152–155
dc.identifier.issn0304-3940
dc.identifier.doi10.1016/j.neulet.2008.12.043
dc.identifier.urihttp://hdl.handle.net/2436/74774
dc.description.abstractShort episodes of high intensity exercise transiently increase serum levels of BDNF in humans, but serum levels of BDNF at rest appear to be lower in more physically active humans with greater levels of energy expenditure. The relationship between serum BDNF concentration, cardio-respiratory fitness (Åstrand–Rhyming test estimated VO2 max) and volume of long-term, regular exercise and sporting activity (Baecke Habitual Physical Activity Index) was investigated in 44 men and women between the age range of 18–57 years. In this group an inverse relationship between resting serum BDNF concentration and measures of both estimated VO2 max (r =−0.352; P < 0.05) and long-term sporting activity (r =−0.428, P < 0.01) was found. These results indicate that increased levels of cardio-respiratory fitness and habitual exercise are associated with lower resting levels of serum BDNF in healthy humans. This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF.
dc.language.isoen
dc.relation.urlhttp://www.elsevier.com/wps/find/journaldescription.cws_home/506081/description#description
dc.subjectBDNF
dc.subjectEstimated VO2 max
dc.subjectPhysical activity
dc.subjectHuman
dc.titleCardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women
dc.typeJournal article
dc.identifier.journalNeuroscience Letters
html.description.abstractShort episodes of high intensity exercise transiently increase serum levels of BDNF in humans, but serum levels of BDNF at rest appear to be lower in more physically active humans with greater levels of energy expenditure. The relationship between serum BDNF concentration, cardio-respiratory fitness (Åstrand–Rhyming test estimated VO2 max) and volume of long-term, regular exercise and sporting activity (Baecke Habitual Physical Activity Index) was investigated in 44 men and women between the age range of 18–57 years. In this group an inverse relationship between resting serum BDNF concentration and measures of both estimated VO2 max (r =−0.352; P < 0.05) and long-term sporting activity (r =−0.428, P < 0.01) was found. These results indicate that increased levels of cardio-respiratory fitness and habitual exercise are associated with lower resting levels of serum BDNF in healthy humans. This is the first study to demonstrate an inverse relationship between a physiological estimate of cardio-respiratory fitness and serum BDNF.


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record