Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Metsios, Giorgos S.
Panoulas, Vasileios F.
Nevill, Alan M.
Jamurtas, Athanasios Z.
Kitas, George D.
MetadataShow full item record
AbstractObesity is characterised by low-grade inflammation and could potentially affect disease activity and severity in patients with rheumatoid arthritis (RA). Body mass index (BMI), body fat (BF), erythrocyte sedimentation rate, C-reactive protein, disease activity score 28, physical function (health assessment questionnaire) and presence of erosions and joint surgery were assessed in 294 (female=219) volunteers with established RA [age 63.3 (56.2-69.6); disease duration 13 (7-20) years]. Smoking status, rheumatoid factor and anti-cyclic citrullinated peptide positivity were also assessed. BMI and BF independently associated with disease characteristics. Compared to normal-weight patients, underweight and obese had higher C-reactive protein (p=0.046) and physical dysfunction (p=0.034). BMI or BF did not associate with presence of erosions or joint surgery. In patients with established RA, both very low and very high BMI and BF associate independently with increased disease activity and physical dysfunction; however, this does not seem to associate with presence of erosions or joint surgery. Further longitudinal studies are required to address this apparent dissociation.
CitationClinical Rheumatology, 28(4): 439-444
- What predicts obesity in patients with rheumatoid arthritis? An investigation of the interactions between lifestyle and inflammation.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Smith JP, Panoulas VF, Douglas KM, Jamurtas AZ, Koutedakis Y, Kitas GD
- Issue date: 2010 Feb
- Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, Douglas KM, Nevill AM, Jamurtas AZ, Kita M, Koutedakis Y, Kitas GD
- Issue date: 2008
- Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis.
- Authors: Rydell E, Forslind K, Nilsson JÅ, Jacobsson LTH, Turesson C
- Issue date: 2018 May 2
- Low body mass index in long standing rheumatoid arthritis: relation to RA disease activity and functional indices.
- Authors: Gamal SM, Alkemary AK, Abdo MA, El Dakrony AHM
- Issue date: 2018 Jul 6
- Body mass index distribution in rheumatoid arthritis: a collaborative analysis from three large German rheumatoid arthritis databases.
- Authors: Albrecht K, Richter A, Callhoff J, Huscher D, Schett G, Strangfeld A, Zink A
- Issue date: 2016 Jun 23