Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis.
Authors
Stavropoulos-Kalinoglou, AntoniosMetsios, Giorgos S.
Panoulas, Vasileios F.
Nevill, Alan M.
Jamurtas, Athanasios Z.
Koutedakis, Yiannis
Kitas, George D.
Issue Date
2009
Metadata
Show full item recordAbstract
Obesity is characterised by low-grade inflammation and could potentially affect disease activity and severity in patients with rheumatoid arthritis (RA). Body mass index (BMI), body fat (BF), erythrocyte sedimentation rate, C-reactive protein, disease activity score 28, physical function (health assessment questionnaire) and presence of erosions and joint surgery were assessed in 294 (female=219) volunteers with established RA [age 63.3 (56.2-69.6); disease duration 13 (7-20) years]. Smoking status, rheumatoid factor and anti-cyclic citrullinated peptide positivity were also assessed. BMI and BF independently associated with disease characteristics. Compared to normal-weight patients, underweight and obese had higher C-reactive protein (p=0.046) and physical dysfunction (p=0.034). BMI or BF did not associate with presence of erosions or joint surgery. In patients with established RA, both very low and very high BMI and BF associate independently with increased disease activity and physical dysfunction; however, this does not seem to associate with presence of erosions or joint surgery. Further longitudinal studies are required to address this apparent dissociation.Citation
Clinical Rheumatology, 28(4): 439-444Publisher
Springer LondonJournal
Clinical RheumatologyPubMed ID
19096748Additional Links
http://www.springerlink.com/content/m0g3322246925q60/Type
Journal articleLanguage
enISSN
1434-9949ae974a485f413a2113503eed53cd6c53
10.1007/s10067-008-1073-z
Scopus Count
Collections
Related articles
- What predicts obesity in patients with rheumatoid arthritis? An investigation of the interactions between lifestyle and inflammation.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Smith JP, Panoulas VF, Douglas KM, Jamurtas AZ, Koutedakis Y, Kitas GD
- Issue date: 2010 Feb
- Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study.
- Authors: Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, Douglas KM, Nevill AM, Jamurtas AZ, Kita M, Koutedakis Y, Kitas GD
- Issue date: 2008
- Low body mass index in long standing rheumatoid arthritis: relation to RA disease activity and functional indices.
- Authors: Gamal SM, Alkemary AK, Abdo MA, El Dakrony AHM
- Issue date: 2018 Jul 6
- Body mass index distribution in rheumatoid arthritis: a collaborative analysis from three large German rheumatoid arthritis databases.
- Authors: Albrecht K, Richter A, Callhoff J, Huscher D, Schett G, Strangfeld A, Zink A
- Issue date: 2016 Jun 23
- Prevalence of overweight in Moroccan patients with rheumatoid arthritis and its relationships with disease features.
- Authors: Ibn Yacoub Y, Amine B, Laatiris A, Wafki F, Znat F, Hajjaj-Hassouni N
- Issue date: 2012 Mar