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Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.

dc.contributor.authorPanoulas, Vasileios F.
dc.contributor.authorDouglas, Karen M. J.
dc.contributor.authorSmith, Jacqueline P.
dc.contributor.authorMetsios, Giorgos S.
dc.contributor.authorElisaf, Moses S.
dc.contributor.authorNightingale, Peter
dc.contributor.authorKitas, George D.
dc.date.accessioned2009-04-30T19:44:39Z
dc.date.available2009-04-30T19:44:39Z
dc.date.issued2009
dc.identifier.citationClinical and Experimental Hypertension, 31(2): 93-104en
dc.identifier.issn1525-6006
dc.identifier.issn0148-3927
dc.identifier.pmid19330599
dc.identifier.doi10.1080/10641960802621267
dc.identifier.urihttp://hdl.handle.net/2436/66833
dc.description.abstractThe galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
dc.language.isoenen
dc.publisherInformaworld (Taylor & Francis)en
dc.relation.urlhttp://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562en
dc.subjectArthritis, Rheumatoiden
dc.subjectPrevalence
dc.subjectRheumatoid Arthritis
dc.subjectCardiovascular Disease
dc.subjectBlood Pressure
dc.subjectHypertension
dc.subjectGalectin-2
dc.subjectLGALS2
dc.subjectrs7291467
dc.subjectPolymorphism
dc.subjectGenetics
dc.titleGalectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.en
dc.typeJournal article
dc.identifier.journalClinical and Experimental Hypertensionen
html.description.abstractThe galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.


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