• Admin Login
    View Item 
    •   Home
    • Faculty of Education, Health and Wellbeing
    • Faculty of Education, Health and Wellbeing
    • View Item
    •   Home
    • Faculty of Education, Health and Wellbeing
    • Faculty of Education, Health and Wellbeing
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WIRECommunitiesTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisherThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsTypesJournalDepartmentPublisher

    Administrators

    Admin Login

    Local Links

    AboutThe University LibraryOpen Access Publications PolicyDeposit LicenceCOREWIRE Copyright and Reuse Information

    Statistics

    Display statistics

    Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Panoulas, Vasileios F.
    Douglas, Karen M. J.
    Smith, Jacqueline P.
    Metsios, Giorgos S.
    Elisaf, Moses S.
    Nightingale, Peter
    Kitas, George D.
    Issue Date
    2009
    
    Metadata
    Show full item record
    Abstract
    The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
    Citation
    Clinical and Experimental Hypertension, 31(2): 93-104
    Publisher
    Informaworld (Taylor & Francis)
    Journal
    Clinical and Experimental Hypertension
    URI
    http://hdl.handle.net/2436/66833
    DOI
    10.1080/10641960802621267
    PubMed ID
    19330599
    Additional Links
    http://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562
    Type
    Journal article
    Language
    en
    ISSN
    1525-6006
    0148-3927
    ae974a485f413a2113503eed53cd6c53
    10.1080/10641960802621267
    Scopus Count
    Collections
    Faculty of Education, Health and Wellbeing

    entitlement

    Related articles

    • Lymphotoxin 252A>G polymorphism is common and associates with myocardial infarction in patients with rheumatoid arthritis.
    • Authors: Panoulas VF, Nikas SN, Smith JP, Douglas KM, Nightingale P, Milionis HJ, Treharne GJ, Toms TE, Kita MD, Kitas GD
    • Issue date: 2008 Nov
    • Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations.
    • Authors: Kimura A, Takahashi M, Choi BY, Bae SW, Hohta S, Sasaoka T, Nakahara KI, Chida K, Sawabe M, Yasunami M, Naruse T, Izumi T, Park JE
    • Issue date: 2007 Mar
    • Polymorphisms of the endothelin-1 gene associate with hypertension in patients with rheumatoid arthritis.
    • Authors: Panoulas VF, Douglas KM, Smith JP, Taffé P, Stavropoulos-Kalinoglou A, Toms TE, Elisaf MS, Nightingale P, Kitas GD
    • Issue date: 2008 Jul-Aug
    • Transforming growth factor-beta1 869T/C, but not interleukin-6 -174G/C, polymorphism associates with hypertension in rheumatoid arthritis.
    • Authors: Panoulas VF, Douglas KM, Smith JP, Stavropoulos-Kalinoglou A, Metsios GS, Nightingale P, Kitas GD
    • Issue date: 2009 Feb
    • Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
    • Authors: Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Mueller JC, Gieger C, Wichmann HE, Meitinger T, Schömig A, Kastrati A
    • Issue date: 2007 Aug 1

    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.