Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.
Authors
Panoulas, Vasileios F.Douglas, Karen M. J.
Smith, Jacqueline P.
Metsios, Giorgos S.
Elisaf, Moses S.
Nightingale, Peter
Kitas, George D.
Issue Date
2009
Metadata
Show full item recordAbstract
The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.Citation
Clinical and Experimental Hypertension, 31(2): 93-104Publisher
Informaworld (Taylor & Francis)Journal
Clinical and Experimental HypertensionPubMed ID
19330599Additional Links
http://www.informaworld.com/smpp/content~content=a909967496?words=panoulas&hash=843258562Type
Journal articleLanguage
enISSN
1525-60060148-3927
ae974a485f413a2113503eed53cd6c53
10.1080/10641960802621267