The global prevalence of vitamin d deficiency and insufficiency in patients with multiple myeloma: a systematic review and meta-analysis
Authors
Ismail, Nor HayatiMussa, Ali
Al-Khreisat, Mutaz Jamal
Mohamed Yusoff, Shafini
Husin, Azlan
Johan, Muhammad Farid
Islam, Md Asiful
Issue Date
2023-07-20
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BACKGROUND: Multiple myeloma (MM) is a hematological malignancy characterized by the exponential growth of malignant plasma cells. Individuals diagnosed with MM exhibit a deficiency in vitamin D and may suffer fatigue, a loss of muscular strength, persistent musculoskeletal aches, and pain. The objective of this systematic review and meta-analysis is to determine the prevalence of vitamin D insufficiency and deficiency in individuals diagnosed with MM. METHODS: We searched five electronic databases using relevant keywords. The quality of the included studies was evaluated using the critical appraisal tool developed by the Joanna Briggs Institute. We employed a random-effects model and presented the findings in the form of percentages accompanied by 95% confidence intervals (CI). This protocol has been officially registered in PROSPERO under the registration number CRD42021248710. RESULTS: The meta-analysis comprised a total of eighteen studies and found that, among patients with MM, the occurrence of serum vitamin D deficiency and insufficiency was 39.4% (95% CI: 25.8 to 52.9, n = 3746) and 34.1% (95% CI: 20.9 to 47.2, n = 3559), respectively. The findings indicate that a greater proportion of newly diagnosed patients exhibited vitamin D deficiency and insufficiency, with rates of 43.0% and 41.6%, respectively, compared to those receiving treatment (rates of 41.6% and 32.3%, respectively). The findings of the sensitivity analyses were consistent, and most of the studies (72.2%) were deemed to be of high quality. The results of Egger's test indicated the absence of publication bias. CONCLUSIONS: Patients diagnosed with MM have been found to exhibit significantly elevated levels of both vitamin D deficiency and insufficiency. Therefore, it is recommended to consider vitamin D testing as an additional parameter in the current criteria for the clinical evaluation of MM.Citation
Ismail NH, Mussa A, Al-Khreisat MJ, Mohamed Yusoff S, Husin A, Johan MF, Islam MA (2023) The Global Prevalence of Vitamin D Deficiency and Insufficiency in Patients with Multiple Myeloma: A Systematic Review and Meta-Analysis. Nutrients. 15 (14) Article no. 3227. https://doi.org/10.3390/nu15143227Publisher
MDPI AGJournal
NutrientsPubMed ID
37513645 (pubmed)Additional Links
https://www.mdpi.com/2072-6643/15/14/3227Type
Journal articleLanguage
enDescription
© 2023 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/nu15143227ISSN
2072-6643EISSN
2072-6643Sponsors
This work was supported by the GIPS-PhD (311/PPSP/4404822) research grant from Universiti Sains Malaysia to M.F.J and N.H.I.ae974a485f413a2113503eed53cd6c53
10.3390/nu15143227
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