Nasal nitric oxide measurement in allergic rhinitis and non-allergic rhinitis: a meta-analysis
Abstract
The goal of this meta-analysis was to study nasal nitric oxide (nNO) measurements in allergic rhinitis (AR) and non-allergic rhinitis (non-AR). The protocol was registered with PROSPERO (no: CRD4202124828). Electronic databases from PubMed, Google Scholar, Scopus, Web of Science, and Cochrane were all thoroughly searched and studies were chosen based on the qualifying requirements. The quality of the studies was evaluated by Joanna Briggs Institute evaluation tools, and publication bias using funnel plots. The meta-analysis included 18 studies, whereas the systematic review included 20 studies, totaling 3097 participants (1581 AR, 458 non-AR, and 1058 healthy/control). Patients with AR had significantly greater nNO levels than the control group, although this did not change significantly before or after treatment. AR patients had significantly greater nNO levels than non-AR patients, but there was no significant difference between non-AR patients and healthy controls. Nineteen of the studies were of high quality and the remaining one was of moderate quality. nNO measurement has a promising role in the management of AR and non-AR patients, but more investigations are needed to document clinical benefits.Citation
Dahlan A.F., Islam M.A., Shukri N.M., et al. Nasal nitric oxide measurement in allergic rhinitis and nonallergic rhinitis: a meta-analysis. Acta Otorhinolaryngolica Italia 44 pp. 100-112Publisher
Pacini EditoreJournal
Acta Otorhinolaryngologica ItalicaPubMed ID
38651552 (pubmed)Additional Links
https://www.actaitalica.it/article/view/2634Type
Journal articleLanguage
enDescription
© 2024 The Authors. Published by Società Italiana di Otorinolaringoiatria e chirurgia cervico facciale. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.14639/0392-100X-N2634ISSN
0392-100XEISSN
1827-675XSponsors
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.ae974a485f413a2113503eed53cd6c53
10.14639/0392-100X-N2634
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Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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