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dc.contributor.authorGillessen, Silke
dc.contributor.authorBossi, Alberto
dc.contributor.authorDavis, Ian D.
dc.contributor.authorde Bono, Johann S.
dc.contributor.authorFizazi, Karim
dc.contributor.authorJames, Nicholas D.
dc.contributor.authorMottet, Nicolas
dc.contributor.authorShore, Neal
dc.contributor.authorSmall, Eric
dc.contributor.authorSmith, Mathew
dc.contributor.authorSweeney, Christopher
dc.contributor.authorTombal, Bertrand
dc.contributor.authorAntonarakis, Emmanuel S.
dc.contributor.authorAparicio, Ana M.
dc.contributor.authorArmstrong, Andrew J.
dc.contributor.authorAttard, Gerhardt
dc.contributor.authorBeer, Tomasz M.
dc.contributor.authorBeltran, Himisha
dc.contributor.authorBjartell, Anders
dc.contributor.authorBlanchard, Pierre
dc.contributor.authorBriganti, Alberto
dc.contributor.authorBristow, Rob G.
dc.contributor.authorBulbul, Muhammad
dc.contributor.authorCaffo, Orazio
dc.contributor.authorCastellano, Daniel
dc.contributor.authorCastro, Elena
dc.contributor.authorCheng, Heather H.
dc.contributor.authorChi, Kim N.
dc.contributor.authorChowdhury, Simon
dc.contributor.authorClarke, Caroline S.
dc.contributor.authorClarke, Noel W.
dc.contributor.authorDaugaard, Gedske
dc.contributor.authorDe Santis, Maria
dc.contributor.authorDuran, Ignacio
dc.contributor.authorEeles, Ros
dc.contributor.authorEfstathiou, Eleni
dc.contributor.authorEfstathiou, Jason
dc.contributor.authorEkeke, Onyeanunam
dc.contributor.authorEvans, Christopher P.
dc.contributor.authorFanti, Stefano
dc.contributor.authorFonteyne, Valerie
dc.contributor.authorFossati, Nicola
dc.contributor.authorFrydenberg, Mark
dc.contributor.authorGeorge, Daniel
dc.contributor.authorGleave, Martin
dc.contributor.authorGravis, Gwenaelle
dc.contributor.authorHalabi, Susan
dc.contributor.authorHeinrich, Daniel
dc.contributor.authorHerrmann, Ken
dc.contributor.authorHigano, Celestia
dc.contributor.authorHofman, Michael S.
dc.contributor.authorHorvath, Lisa G.
dc.contributor.authorHussain, Maha
dc.contributor.authorJereczek-Fossa, Barbara Alicja
dc.contributor.authorJones, Robert
dc.contributor.authorKanesvaran, Ravindran
dc.contributor.authorKellokumpu-Lehtinen, Pirkko-Liisa
dc.contributor.authorKhauli, Raja B.
dc.contributor.authorKlotz, Laurence
dc.contributor.authorKramer, Gero
dc.contributor.authorLeibowitz, Raya
dc.contributor.authorLogothetis, Christopher J.
dc.contributor.authorMahal, Brandon A.
dc.contributor.authorMaluf, Fernando
dc.contributor.authorMateo, Joaquin
dc.contributor.authorMatheson, David
dc.contributor.authorMehra, Niven
dc.contributor.authorMerseburger, Axel
dc.contributor.authorMorgans, Alicia K
dc.contributor.authorMorris, Michael J.
dc.contributor.authorMrabti, Hind
dc.contributor.authorMukherji, Deborah
dc.contributor.authorMurphy, Declan G.
dc.contributor.authorMurthy, Vedang
dc.contributor.authorNguyen, Paul L.
dc.contributor.authorOh, William K.
dc.contributor.authorOst, Piet
dc.contributor.authorO’Sullivan, Joe M.
dc.contributor.authorPadhani, Anwar R.
dc.contributor.authorPezaro, Carmel J
dc.contributor.authorPoon, Darren M.C.
dc.contributor.authorPritchard, Colin C.
dc.contributor.authorRabah, Danny M.
dc.contributor.authorRathkopf, Dana
dc.contributor.authorReiter, Robert E.
dc.contributor.authorRubin, Mark A.
dc.contributor.authorRyan, Charles J.
dc.contributor.authorSaad, Fred
dc.contributor.authorSade, Juan Pablo
dc.contributor.authorSartor, Oliver A.
dc.contributor.authorScher, Howard I.
dc.contributor.authorSharifi, Nima
dc.contributor.authorSkoneczna, Iwona
dc.contributor.authorSoule, Howard
dc.contributor.authorSpratt, Daniel E.
dc.contributor.authorSrinivas, Sandy
dc.contributor.authorSternberg, Cora N.
dc.contributor.authorSteuber, Thomas
dc.contributor.authorSuzuki, Hiroyoshi
dc.contributor.authorSydes, Matthew R.
dc.contributor.authorTaplin, Mary-Ellen
dc.contributor.authorTilki, Derya
dc.contributor.authorTürkeri, Levent
dc.contributor.authorTurco, Fabio
dc.contributor.authorUemura, Hiroji
dc.contributor.authorUemura, Hirotsugu
dc.contributor.authorÜrün, Yüksel
dc.contributor.authorVale, Claire L.
dc.contributor.authorvan Oort, Inge
dc.contributor.authorVapiwala, Neha
dc.contributor.authorWalz, Jochen
dc.contributor.authorYamoah, Kosj
dc.contributor.authorYe, Dingwei
dc.contributor.authorYu, Evan Y.
dc.contributor.authorZapatero, Almudena
dc.contributor.authorZilli, Thomas
dc.contributor.authorOmlin, Aurelius
dc.identifier.citationGillessen, S., Bossi, A., Davis, I.D. et al. (2023) Management of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022. European Journal of Cancer, 185, P178-215.en
dc.description© 2023 The Authors. Published by Elsevier. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website:
dc.description.abstractBackground: Innovations in imaging and molecular characterisation together with novel treatment options have improved outcomes in advanced prostate cancer. However, we still lack high-level evidence in many areas relevant to making management decisions in daily clinical practise. The 2022 Advanced Prostate Cancer Consensus Conference (APCCC 2022) addressed some questions in these areas to supplement guidelines that mostly are based on level 1 evidence. Objective: To present the voting results of the APCCC 2022. Design, setting, and participants: The experts voted on controversial questions where high-level evidence is mostly lacking: locally advanced prostate cancer; biochemical recurrence after local treatment; metastatic hormone-sensitive, non-metastatic, and metastatic castration-resistant prostate cancer; oligometastatic prostate cancer; and managing side effects of hormonal therapy. A panel of 105 international prostate cancer experts voted on the consensus questions. Outcome measurements and statistical analysis: The panel voted on 198 pre-defined questions, which were developed by 117 voting and non-voting panel members prior to the conference following a modified Delphi process. A total of 116 questions on metastatic and/or castration-resistant prostate cancer are discussed in this manuscript. In 2022, the voting was done by a web-based survey because of COVID-19 restrictions. Results and limitations: The voting reflects the expert opinion of these panellists and did not incorporate a standard literature review or formal meta-analysis. The answer options for the consensus questions received varying degrees of support from panellists, as reflected in this article and the detailed voting results are reported in the supplementary material. We report here on topics in metastatic, hormone-sensitive prostate cancer (mHSPC), non-metastatic, castration-resistant prostate cancer (nmCRPC), metastatic castration-resistant prostate cancer (mCRPC), and oligometastatic and oligoprogressive prostate cancer. Conclusions: These voting results in four specific areas from a panel of experts in advanced prostate cancer can help clinicians and patients navigate controversial areas of management for which high-level evidence is scant or conflicting and can help research funders and policy makers identify information gaps and consider what areas to explore further. However, diagnostic and treatment decisions always have to be individualised based on patient characteristics, including the extent and location of disease, prior treatment(s), co-morbidities, patient preferences, and treatment recommendations and should also incorporate current and emerging clinical evidence and logistic and economic factors. Enrolment in clinical trials is strongly encouraged. Importantly, APCCC 2022 once again identified important gaps where there is non-consensus and that merit evaluation in specifically designed trials. Patient summary: The Advanced Prostate Cancer Consensus Conference (APCCC) provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference aims to share the knowledge of international experts in prostate cancer with healthcare providers worldwide. At each APCCC, an expert panel votes on pre-defined questions that target the most clinically relevant areas of advanced prostate cancer treatment for which there are gaps in knowledge. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients and their relatives as part of shared and multidisciplinary decision-making. This report focuses on the advanced setting, covering metastatic hormone-sensitive prostate cancer and both non-metastatic and metastatic castration-resistant prostate cancer. Twitter summary: Report of the results of APCCC 2022 for the following topics: mHSPC, nmCRPC, mCRPC, and oligometastatic prostate cancer. Take-home message: At APCCC 2022, clinically important questions in the management of advanced prostate cancer management were identified and discussed, and experts voted on pre-defined consensus questions. The report of the results for metastatic and/or castration-resistant prostate cancer is summarised here.en
dc.subjectmetastatic hormone-sensitive prostate canceren
dc.subjectnon metastatic castration-resistant prostate canceren
dc.subjectmetastatic castration-resistant prostate canceren
dc.subjectoligometastatic and oligoprogressive prostate canceren
dc.subjecthormonal treatmenten
dc.subjectsystemic therapyen
dc.subjectandrogen receptor pathway inhibitorsen
dc.subjectnext-generation imagingen
dc.subjectPSMA PET-imagingen
dc.titleManagement of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022en
dc.typeConference contributionen
dc.identifier.journalEuropean Journal of Canceren
rioxxterms.funderUniversity of Wolverhamptonen
dc.description.versionPublished version

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