Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study
Authors
Ma, YingWu, Yu
Zhang, Yi
Jiao, Ting
Guo, Shuangshuang
Zhang, Dongying
Yang, Jiewen
Deng, Nali
Lang, Zhijiang
Wang, Harry H.X.
Bao, Wei
Chen, Ruoling
Tang, Jie
Liu, Xiaoqin
Issue Date
2023-04-11
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Background Studies on the associations between maternal complications during pregnancy and childhood asthma are exclusively conducted in Western countries. The findings are mixed and may not be translated to other populations. We aimed to investigate the associations among the Chinese population and to determine whether the associations were mediated through pre-term birth, caesarean delivery, low birthweight and not breastfeeding in the first 6 months. Methods We conducted a retrospective cohort study of 166 772 children in Guangzhou, China. Information on maternal gestational hypertension, gestational diabetes and gestational anaemia during pregnancy was extracted from medical records. Ever-diagnosis of asthma in children aged 6–12 years was obtained by questionnaire. Logistic regression models and mediation analyses were used to estimate the adjusted odds ratios (aORs) and 95% confidence intervals for childhood asthma. Results Gestational hypertension, gestational diabetes and gestational anaemia during pregnancy were associated with an increased risk of ever-diagnosed childhood asthma: aOR 1.48 (95% CI 1.37–1.60), 1.71 (95% CI 1.65–1.78) and 1.34 (95% CI 1.26–1.45), respectively. A stronger association was observed for two or three gestational complications (aOR 2.02 (95% CI 1.93–2.16)) than one gestational complication (aOR 1.64 (95% CI 1.52–1.77)). The aOR for the three gestational complications was 1.35 (95% CI 1.26–1.45), 1.63 (95% CI 1.58–1.70) and 1.32 (95% CI 1.24–1.43), respectively, after controlling for the mediators, including pre-term birth, caesarean delivery, low birthweight and not breastfeeding in the first 6 months. Conclusions Gestational hypertension, gestational diabetes and gestational anaemia were associated with childhood asthma, and the associations were partially explained by the mediation effects.Citation
Ma, Y., Wu, Y., Zhang, Y., Jiao, T., Guo, S., Zhang, D., Yang, J., Deng, N., Liang, Z., Wang, H.H.X., Bao, W., Chen, R., Tang, J. and Liu, X. (2023) Associations between maternal complications during pregnancy and childhood asthma: a retrospective cohort study. ERJ Open Research, 9(2), 00548-2022; DOI: 10.1183/23120541.00548-2022Publisher
European Respiratory SocietyJournal
ERJ Open ResearchPubMed ID
37057092 (pubmed)Additional Links
https://openres.ersjournals.com/content/9/2/00548-2022Type
Journal articleLanguage
enDescription
© 2023 The Authors. Published by the European Respiratory Society. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://openres.ersjournals.com/content/9/2/00548-2022ISSN
2312-0541EISSN
2312-0541Sponsors
This study was supported by National Natural Science Foundation of China (82073571 and 81773457 to J. Tang).ae974a485f413a2113503eed53cd6c53
10.1183/23120541.00548-2022
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Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution-NonCommercial 4.0 International
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