Show simple item record

dc.contributor.authorTorof, Elham
dc.contributor.authorMorrissey, Hana
dc.contributor.authorBall, Patrick
dc.date.accessioned2023-04-06T10:19:18Z
dc.date.available2023-04-06T10:19:18Z
dc.date.issued2023-04-05
dc.identifier.citationTorof, E., Morrissey, H., Ball, P.A. (2023) Antibiotic Use in Dental Implant Procedures: A Systematic Review and Meta-Analysis. Medicina, 59(4):713. https://doi.org/10.3390/medicina59040713en
dc.identifier.issn1010-660Xen
dc.identifier.doi10.3390/medicina59040713en
dc.identifier.urihttp://hdl.handle.net/2436/625163
dc.description© 2023 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/medicina59040713en
dc.description.abstractBackground and Objectives: This project was developed from anecdotal evidence of varied practices around antibiotic prescribing in dental procedures. The aim of the study was to ascertain if there is evidence to support whether antibiotic (AB) use can effectively reduce postoperative infections after dental implant placements (DIPs). Materials and Methods: Following PRISMA-P© methodology, a systematic review of randomised controlled clinical trials was designed and registered on the PROSPERO© database. Searches were performed using PubMed®, Science Direct® and the Cochrane© Database, plus the bibliographies of studies identified. The efficacy of prophylactic antibiotics, independent of the regimen used, versus a placebo, control or no therapy based on implant failure due to infection was the primary measured outcome. Secondary outcomes were other post-surgical complications due to infection and AB adverse events. Results: Twelve RCTs were identified and analysed. Antibiotic use was reported to be statistically significant in preventing infection (p < 001). The prevention of complications was not statistically significant (p = 0.96), and the NNT was >5 (14 and 2523 respectively), which indicates that the intervention was not sufficiently effective to justify its use. The occurrence of side effects was not statistically significant (p = 0.63). NNH was 528 indicating that possible harm caused by the use of ABs is very small and does not negate the AB use when indicated. Conclusion: The routine use of prophylactic antibiotics to prevent infection in dental implant placement was found to be not sufficiently effective to justify routine use. Clear clinical assessment pathways, such as those used for medical conditions, based on the patients’ age, dental risk factors, such as oral health and bone health, physical risk factors, such as chronic or long-term conditions and modifiable health determinants, such as smoking, are required to prevent the unnecessary use of antibiotics.en
dc.formatapplication/pdfen
dc.languageEnglish
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urlhttps://www.mdpi.com/1648-9144/59/4/713en
dc.subjectpre-operative antibiotics and post-operative complications implant failuretibiotic prophylaxixen
dc.subjectdental implant failureen
dc.subjectantibiotic prophylaxis in dentistryen
dc.subjectdental implant placementen
dc.titleAntibiotic use in dental implant procedures: A systematic review and meta-analysisen
dc.typeJournal articleen
dc.identifier.eissn1648-9144
dc.identifier.journalMedicinaen
dc.date.updated2023-04-05T12:01:58Z
dc.identifier.articlenumber713
dc.date.accepted2023-04-04
rioxxterms.funderUniversity of Wolverhamptonen
rioxxterms.identifier.projectUOW06042023HMen
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2023-04-06en
dc.source.volume59
dc.source.issue4
dc.source.beginpage1
refterms.dateFCD2023-04-06T10:19:08Z
refterms.versionFCDVoR
refterms.dateFOA2023-04-06T10:19:19Z


Files in this item

Thumbnail
Name:
medicina-59-00713.pdf
Size:
23.38Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/