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dc.contributor.authorSethi, Sonika
dc.contributor.authorManuelpillai, Natasha
dc.contributor.authorMandal, Anandadeep
dc.contributor.authorSimpson, Olivia
dc.contributor.authorMorrissey, Hana
dc.contributor.authorBall, Patrick
dc.contributor.authorSharrod-Cole, Hayley
dc.contributor.authorFord, Clare
dc.contributor.authorWhittaker, Anna C.
dc.contributor.authorDrayson, Mark
dc.contributor.authorRace, Adam
dc.contributor.authorBateman, James
dc.contributor.authorBasu, Supratik
dc.contributor.authorCotton, James M.
dc.date.accessioned2023-02-28T10:06:54Z
dc.date.available2023-02-28T10:06:54Z
dc.date.issued2022-08-11
dc.identifier.citationSethi, S., Manuelpillai, N., Mandal, A. et al. (2022) COVID-19 seroprevalence after the first UK wave of the pandemic and its association with the physical and mental wellbeing of secondary care healthcare workers. Brain, Behavior, and Immunity - Health, 24, 100492.en
dc.identifier.issn2666-3546en
dc.identifier.pmid35957800 (pubmed)
dc.identifier.doi10.1016/j.bbih.2022.100492en
dc.identifier.urihttp://hdl.handle.net/2436/625126
dc.description© 2022 The Authors. Published by Elsevier. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1016/j.bbih.2022.100492en
dc.description.abstractObjectives: To determine the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibody status amongst healthcare workers (HCWs) working through the first wave of the Coronavirus (COVID-19) pandemic in 2020. To examine the association of seroprevalence and self-reported COVID-19 symptoms with occupation, sex, and ethnicity; and how these factors were associated with physical and mental wellbeing. Design: Single-centre cohort study. Setting: Large public hospital in the United Kingdom. Intervention: All HCWs who had been tested for anti-SARS-CoV-2 immunoglobulin (Ig) G nucleocapsid antibody in summer 2020 were asked to complete an electronic survey focusing on their physical and mental health in Winter 2020–21. This survey was comprised of the Short Form 12v2, Physical Component Summary (PCS), Mental Component Summary (MCS), and Generalised Anxiety Disorder 7-item (GAD-7) questionnaires. Results: 7604/9781 (77.7%) HCWs were antibody tested, of which 1082 completed the full survey. Antibody testing was conducted between 17/06/20–30/07/20, during which time our seroprevalence rate was 28% (299/1082). Of those self-reporting COVID-19 symptoms, 51% (201/395) were antibody positive. Antibody-positive participants had lower PCS scores (p = 0.016), indicating poorer physical health. Lower PCS scores were also found in those deemed high risk for COVID-19 by their GP (p = 0.001), and those aged >44 years (p = 0.009). Antibody-negative participants had lower MCS scores (p = 0.044), indicating poorer mental health. Those who self-reported COVID-19 symptoms had lower PCS scores (p=<0.001) than those with no symptoms. Lower MCS scores were found in women (p = 0.001), Caucasians (p = 0.018), non-clinicians (p = 0.001), and those aged <44 years (p = 0.009). Significantly higher GAD-7 anxiety scores were evident in staff aged <44 years (p = 0.023), and those with self-reported COVID symptoms (p = 0.031). Doctors had lower GAD-7 anxiety scores (p = 0.009). Conclusion: Self-reported symptoms did not correlate with seroprevalence; data surrounding this can be useful for future workforce planning. Interventions are needed to reduce the mental and physical burden of the pandemic on HCWs. Further work is needed to identify which particular HCWs may require further support, to ensure well-being and effective patient care. Trial registration: Sponsor Protocol number - 2020COV112, Clinicaltrials.gov number -NCT04527432.en
dc.description.sponsorshipThis work was supported by National Institute of Health and Care Research (sponsor number 2020COV112). Abbott Laboratories provided the SARS-CoV-2 Immunoglobin (Ig) test kits used in this study.en
dc.formatapplication/pdfen
dc.languageeng
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S2666354622000825?via%3Dihuben
dc.rightsLicence for published version: Creative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGAD-7©en
dc.subjecthealthcare professionalsen
dc.subjectmental health and wellbeingen
dc.subjectphysical healthen
dc.subjectSARS-CoV-2en
dc.subjectSF-12©en
dc.subjectanxietyen
dc.subjectCOVID-19en
dc.subjectfrontline workersen
dc.subjectresilienceen
dc.titleCOVID-19 seroprevalence after the first UK wave of the pandemic and its association with the physical and mental wellbeing of secondary care healthcare workersen
dc.typeJournal articleen
dc.identifier.eissn2666-3546
dc.identifier.journalBrain, Behavior, and Immunity - Healthen
dc.date.updated2023-02-27T10:38:31Z
dc.contributor.institutionThe Royal Wolverhampton NHS Trust, Wolverhampton, UK.
dc.identifier.articlenumber100492
pubs.place-of-publicationUnited States
dc.date.accepted2022-07-18
rioxxterms.funderNational Institute of Health and Care Researchen
rioxxterms.identifier.project2020COV112en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2023-02-28en
dc.source.volume24
dc.source.beginpage1
dc.description.versionPublished version
refterms.dateFCD2023-02-28T10:06:44Z
refterms.versionFCDVoR
refterms.dateFOA2023-02-28T10:06:55Z


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Licence for published version: Creative Commons Attribution 4.0 International
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