Bioactive bacterial cellulose wound dressings for burns with collagen in-situ and chitosan ex-situ impregnation
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Authors
Pasaribu, Khatarina MeldawatiIlyas, Syafruddin
Tamrin, Tamrin
Radecka, Izabela
Swingler, Sam
Gupta, Abhishek
Stamboulis, Artemis G
Gea, Saharman
Issue Date
2023-01-10
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Bacterial cellulose (BC) is a biopolymer that commonly used for wound dressings regarding to its high in-vitro and in-vivo biocompatibility. Moreover, the three-dimensional fibers in BC become an advantageous for bioactive wound dressing application as they serve as templates for impregnation other supportive materials. Chitosan and collagen are two of the materials that can be impregnated to optimize the BC properties for serve as wound dressing material. Collagen can help skin cells grow on the wound sites, where chitosan has anti-bacterial properties and can bind red blood cells. BC-based wound dressings were made by impregnating collagen via in-situ method followed by immersing chitosan via ex-situ method into BC fibers for 24 h. The intermolecular interactions of amine groups in the wound dressing were confirmed by FTIR. The XRD diffractogram showed wider peaks at 14.2°, 16.6°, and 22.4° due to the presence of collagen and chitosan molecules in the BC fibers. SEM images confirmed that chitosan and collagen could penetrate BC fibers well. Other tests, such as water content, porosity, antibacterial properties, and haemocompatibility, indicated that the wound dressing was non-hemolytic. In-vivo test indicated that BC/collagen/chitosan wound dressing supported the wound healing process on second degree burn.Citation
Pasaribu, K.M., Ilyas, S., Tamrin, T., Radecka, I., Swingler, S., Gupta, A., Stamboulis, A. and Gea, S. (2023) Bioactive bacterial cellulose wound dressings for burns with collagen in-situ and chitosan ex-situ impregnation. International Journal of Biological Macromolecules, 230, Article no. 123118. https://doi.org/10.1016/j.ijbiomac.2022.123118Publisher
ElsevierJournal
International Journal of Biological MacromoleculesType
Journal articleLanguage
enDescription
This is an accepted manuscript of an article published by Elsevier on 10/01/2023, available online: https://doi.org/10.1016/j.ijbiomac.2022.123118 The accepted version of the publication may differ from the final published version.ISSN
0141-8130Sponsors
This research was fully funded by the Ministry of Research, Technology, and Higher Education (KEMENRISTEK DIKTI) of the Republic of Indonesia via PMDSU research scheme 2020 (Grant No. 181/UN5.2.3.1/PPM/KP-DPRP/2020).ae974a485f413a2113503eed53cd6c53
10.1016/j.ijbiomac.2022.123118
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/