The effect of dietary carbohydrate and fat manipulation on the metabolome and markers of glucose and insulin metabolism: A randomised parallel trial
Boddy, Lynne M.
Enright, Kevin J.
Schmidt, Michael A.
Lane, Katie E
Stewart, Claire E.
MetadataShow full item record
AbstractHigh carbohydrate, lower fat (HCLF) diets are recommended to reduce cardiometabolic disease (CMD) but low carbohydrate high fat (LCHF) diets can be just as effective. The effect of LCHF on novel insulin resistance biomarkers and the metabolome has not been fully explored. The aim of this study was to investigate the impact of an ad libitum 8-week LCHF diet compared with a HCLF diet on CMD markers, the metabolome, and insulin resistance markers. n = 16 adults were randomly assigned to either LCHF (n = 8, <50 g CHO p/day) or HCLF diet (n = 8) for 8 weeks. At weeks 0, 4 and 8, participants provided fasted blood samples, measures of body composition, blood pressure and dietary intake. Samples were analysed for markers of cardiometabolic disease and underwent non-targeted metabolomic profiling. Both a LCHF and HCLF diet significantly (p < 0.01) improved fasting insulin, HOMA IR, rQUICKI and leptin/adiponectin ratio (p < 0.05) levels. Metabolomic profiling detected 3489 metabolites with 78 metabolites being differentially regulated, for example, an upregulation in lipid metabolites following the LCHF diet may indicate an increase in lipid transport and oxidation, improving insulin sensitivity. In conclusion, both diets may reduce type 2 diabetes risk albeit, a LCHF diet may enhance insulin sensitivity by increasing lipid oxidation.
CitationMcCullough D, Harrison T, Boddy LM, Enright KJ, Amirabdollahian F, Schmidt MA, Doenges K, Quinn K, Reisdorph N, Mazidi M, Lane KE, Stewart CE, Davies IG. (2022) The Effect of Dietary Carbohydrate and Fat Manipulation on the Metabolome and Markers of Glucose and Insulin Metabolism: A Randomised Parallel Trial. Nutrients, 14(18):3691. https://doi.org/10.3390/nu14183691
PubMed ID36145067 (pubmed)
Description© 2022 The Authors. Published by MDPI. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3390/nu14183691
SponsorsDeaglan McCullough and Tanja Harrison received funding for a PhD studentship by Liverpool John Moores University.
Except where otherwise noted, this item's license is described as Licence for published version: Creative Commons Attribution 4.0 International
- The Effect of Dietary Carbohydrate and Fat Manipulation on the Metabolome and Markers of Glucose and Insulin Metabolism: A Randomised Parallel Trial.
- Authors: McCullough D, Harrison T, Boddy LM, Enright KJ, Amirabdollahian F, Schmidt MA, Doenges K, Quinn K, Reisdorph N, Mazidi M, Lane KE, Stewart CE, Davies IG
- Issue date: 2022 Sep 7
- Mathematical model of diabetes and lipid metabolism linked to diet, leptin sensitivity, insulin sensitivity and VLDLTG clearance predicts paths to health and type II diabetes.
- Authors: Hassell Sweatman CZW
- Issue date: 2020 Feb 7
- Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice.
- Authors: Keipert S, Voigt A, Klaus S
- Issue date: 2011 Feb
- High Rates of Fat Oxidation Induced by a Low-Carbohydrate, High-Fat Diet, Do Not Impair 5-km Running Performance in Competitive Recreational Athletes.
- Authors: Prins PJ, Noakes TD, Welton GL, Haley SJ, Esbenshade NJ, Atwell AD, Scott KE, Abraham J, Raabe AS, Buxton JD, Ault DL
- Issue date: 2019 Dec